The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.

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Title: The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.
Authors: Qin Z; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242., Bonifati S; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210., St Gelais C; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210., Li TW; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210., Kim SH; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210., Antonucci JM; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210., Mahboubi B; Center for Drug Discovery, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322., Yount JS; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio 43210., Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520., Kim B; Center for Drug Discovery, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322., Wu L; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio 43210. Electronic address: li-wu@uiowa.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2020 Feb 07; Vol. 295 (6), pp. 1575-1586. Date of Electronic Publication: 2019 Dec 30.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.
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  Data: <searchLink fieldCode="AU" term="%22Qin+Z%22">Qin Z</searchLink>; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.<br /><searchLink fieldCode="AU" term="%22Bonifati+S%22">Bonifati S</searchLink>; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.<br /><searchLink fieldCode="AU" term="%22St+Gelais+C%22">St Gelais C</searchLink>; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.<br /><searchLink fieldCode="AU" term="%22Li+TW%22">Li TW</searchLink>; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.<br /><searchLink fieldCode="AU" term="%22Kim+SH%22">Kim SH</searchLink>; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.<br /><searchLink fieldCode="AU" term="%22Antonucci+JM%22">Antonucci JM</searchLink>; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.<br /><searchLink fieldCode="AU" term="%22Mahboubi+B%22">Mahboubi B</searchLink>; Center for Drug Discovery, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322.<br /><searchLink fieldCode="AU" term="%22Yount+JS%22">Yount JS</searchLink>; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio 43210.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520.<br /><searchLink fieldCode="AU" term="%22Kim+B%22">Kim B</searchLink>; Center for Drug Discovery, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio 43210. Electronic address: li-wu@uiowa.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2020 Feb 07; Vol. 295 (6), pp. 1575-1586. <i>Date of Electronic Publication: </i>2019 Dec 30.
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  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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        Value: 10.1074/jbc.RA119.010360
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              Text: 2020 Feb 07
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