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Environmental arginine controls multinuclear giant cell metabolism and formation.

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Title: Environmental arginine controls multinuclear giant cell metabolism and formation.
Authors: Brunner JS; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, 1090, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, 1090, Vienna, Austria., Vulliard L; CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences, 1090, Vienna, Austria., Hofmann M; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, 1090, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, 1090, Vienna, Austria., Kieler M; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, 1090, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, 1090, Vienna, Austria., Lercher A; CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences, 1090, Vienna, Austria., Vogel A; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, 1090, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, 1090, Vienna, Austria., Russier M; Max Planck Institute of Biochemistry, 82152, Martinsried, Germany., Brüggenthies JB; Max Planck Institute of Biochemistry, 82152, Martinsried, Germany., Kerndl M; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, 1090, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, 1090, Vienna, Austria., Saferding V; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Niederreiter B; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Junza A; CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029, Madrid, Spain.; Metabolomics Platform, IISPV, Department of Electronic Engineering, Universitat Rovira i Virgili, 43204, Tarragona, Spain., Frauenstein A; Max Planck Institute of Biochemistry, 82152, Martinsried, Germany., Scholtysek C; Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, 91054, Erlangen, Germany., Mikami Y; Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD, Bethesda, MD, 20892, USA.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan., Klavins K; CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences, 1090, Vienna, Austria., Krönke G; Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, 91054, Erlangen, Germany., Bergthaler A; CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences, 1090, Vienna, Austria., O'Shea JJ; Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD, Bethesda, MD, 20892, USA., Weichhart T; Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, 1090, Vienna, Austria., Meissner F; Max Planck Institute of Biochemistry, 82152, Martinsried, Germany., Smolen JS; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria., Cheng P; Bio Cancer Treatment International Ltd., 999077, Hong Kong, China., Yanes O; CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029, Madrid, Spain.; Metabolomics Platform, IISPV, Department of Electronic Engineering, Universitat Rovira i Virgili, 43204, Tarragona, Spain., Menche J; CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences, 1090, Vienna, Austria., Murray PJ; Max Planck Institute of Biochemistry, 82152, Martinsried, Germany., Sharif O; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, 1090, Vienna, Austria.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, 1090, Vienna, Austria., Blüml S; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, 1090, Vienna, Austria. stephan.blueml@meduniwien.ac.at.; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria. stephan.blueml@meduniwien.ac.at., Schabbauer G; Institute for Vascular Biology, Centre for Physiology and Pharmacology, Medical University Vienna, 1090, Vienna, Austria. gernot.schabbauer@meduniwien.ac.at.; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, 1090, Vienna, Austria. gernot.schabbauer@meduniwien.ac.at.
Source: Nature communications [Nat Commun] 2020 Jan 22; Vol. 11 (1), pp. 431. Date of Electronic Publication: 2020 Jan 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-020-14285-1