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Proteolysis-targeting chimeras in drug development: A safety perspective.

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Title: Proteolysis-targeting chimeras in drug development: A safety perspective.
Authors: Moreau K; Oncology Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, UK., Coen M; Oncology Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, UK., Zhang AX; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts., Pachl F; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts., Castaldi MP; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts., Dahl G; Structure, Biophysics and Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Boyd H; Business Planning and Operations, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Scott C; Oncology Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Boston, Massachusetts., Newham P; Oncology Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, UK.
Source: British journal of pharmacology [Br J Pharmacol] 2020 Apr; Vol. 177 (8), pp. 1709-1718. Date of Electronic Publication: 2020 Feb 25.
Publication Type: Journal Article; Review
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Moreau+K%22">Moreau K</searchLink>; Oncology Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Coen+M%22">Coen M</searchLink>; Oncology Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+AX%22">Zhang AX</searchLink>; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Pachl+F%22">Pachl F</searchLink>; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Castaldi+MP%22">Castaldi MP</searchLink>; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Dahl+G%22">Dahl G</searchLink>; Structure, Biophysics and Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Boyd+H%22">Boyd H</searchLink>; Business Planning and Operations, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Scott+C%22">Scott C</searchLink>; Oncology Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Newham+P%22">Newham P</searchLink>; Oncology Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, UK.
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              Text: 2020 Apr
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