Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module.

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Title: Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module.
Authors: Di Magno L; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Rome, Italy., Manni S; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Di Pastena F; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Coni S; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Macone A; Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, 00185 Rome, Italy., Cairoli S; Division of Metabolism and Research Unit of metabolic Biochemistry, Children's Hospital and Research Institute Bambino Gesù IRCCS, 00146 Rome, Italy., Sambucci M; IRCCS Santa Lucia Foundation, Neuroimmunology Unit, 00143 Rome, Italy., Infante P; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Rome, Italy., Moretti M; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Petroni M; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Nicoletti C; Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Unit of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, Italy., Capalbo C; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., De Smaele E; Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy., Di Marcotullio L; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy., Giannini G; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Battistini L; IRCCS Santa Lucia Foundation, Neuroimmunology Unit, 00143 Rome, Italy., Goffredo BM; Division of Metabolism and Research Unit of metabolic Biochemistry, Children's Hospital and Research Institute Bambino Gesù IRCCS, 00146 Rome, Italy., Iorio E; Core Facilities, Istituto Superiore di Sanità, 00161 Rome, Italy., Agostinelli E; Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, 00185 Rome, Italy; International Polyamines Foundation-ONLUS, 00159 Rome, Italy., Maroder M; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Canettieri G; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy; International Polyamines Foundation-ONLUS, 00159 Rome, Italy. Electronic address: gianluca.canettieri@uniroma1.it.
Source: Cell reports [Cell Rep] 2020 Feb 11; Vol. 30 (6), pp. 1735-1752.e7.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Di+Magno+L%22">Di Magno L</searchLink>; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Manni+S%22">Manni S</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Pastena+F%22">Di Pastena F</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Coni+S%22">Coni S</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Macone+A%22">Macone A</searchLink>; Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, 00185 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cairoli+S%22">Cairoli S</searchLink>; Division of Metabolism and Research Unit of metabolic Biochemistry, Children's Hospital and Research Institute Bambino Gesù IRCCS, 00146 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Sambucci+M%22">Sambucci M</searchLink>; IRCCS Santa Lucia Foundation, Neuroimmunology Unit, 00143 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Infante+P%22">Infante P</searchLink>; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Moretti+M%22">Moretti M</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Petroni+M%22">Petroni M</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Nicoletti+C%22">Nicoletti C</searchLink>; Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Unit of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Capalbo+C%22">Capalbo C</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Smaele+E%22">De Smaele E</searchLink>; Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Marcotullio+L%22">Di Marcotullio L</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Giannini+G%22">Giannini G</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Battistini+L%22">Battistini L</searchLink>; IRCCS Santa Lucia Foundation, Neuroimmunology Unit, 00143 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Goffredo+BM%22">Goffredo BM</searchLink>; Division of Metabolism and Research Unit of metabolic Biochemistry, Children's Hospital and Research Institute Bambino Gesù IRCCS, 00146 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Iorio+E%22">Iorio E</searchLink>; Core Facilities, Istituto Superiore di Sanità, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Agostinelli+E%22">Agostinelli E</searchLink>; Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, 00185 Rome, Italy; International Polyamines Foundation-ONLUS, 00159 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Maroder+M%22">Maroder M</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Canettieri+G%22">Canettieri G</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy; International Polyamines Foundation-ONLUS, 00159 Rome, Italy. Electronic address: gianluca.canettieri@uniroma1.it.
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