View in EDS

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.

Saved in:
Bibliographic Details
Title: Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
Authors: Oshima N; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Ishida R; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Kishimoto S; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Beebe K; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Brender JR; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Yamamoto K; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Urban D; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Rai G; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Johnson MS; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Benavides G; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Squadrito GL; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Crooks D; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Jackson J; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Joshi A; Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland., Mott BT; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Shrimp JH; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Moses MA; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Lee MJ; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Yuno A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Lee TD; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Hu X; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Anderson T; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Kusewitt D; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Hathaway HH; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Jadhav A; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Picard D; Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland., Trepel JB; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Mitchell JB; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Stott GM; Leidos Biomedical, Frederick National Laboratory for Cancer Research, Frederick, MD 24060, USA., Moore W; Leidos Biomedical, Frederick National Laboratory for Cancer Research, Frederick, MD 24060, USA., Simeonov A; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Sklar LA; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Norenberg JP; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Linehan WM; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Maloney DJ; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Dang CV; Ludwig Institute for Cancer Research, New York, NY 10017, USA; The Wistar Institute, Philadelphia, PA 19104, USA., Waterson AG; Department of Chemistry, Vanderbilt University, Nashville, TN 37240, USA., Hall M; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Darley-Usmar VM; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Krishna MC; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Neckers LM; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: neckersl@mail.nih.gov.
Source: Cell reports [Cell Rep] 2020 Feb 11; Vol. 30 (6), pp. 1798-1810.e4.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 32049011
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Oshima+N%22">Oshima N</searchLink>; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Ishida+R%22">Ishida R</searchLink>; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Kishimoto+S%22">Kishimoto S</searchLink>; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Beebe+K%22">Beebe K</searchLink>; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Brender+JR%22">Brender JR</searchLink>; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Yamamoto+K%22">Yamamoto K</searchLink>; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Urban+D%22">Urban D</searchLink>; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Rai+G%22">Rai G</searchLink>; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+MS%22">Johnson MS</searchLink>; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22Benavides+G%22">Benavides G</searchLink>; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22Squadrito+GL%22">Squadrito GL</searchLink>; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22Crooks+D%22">Crooks D</searchLink>; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+J%22">Jackson J</searchLink>; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Joshi+A%22">Joshi A</searchLink>; Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mott+BT%22">Mott BT</searchLink>; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Shrimp+JH%22">Shrimp JH</searchLink>; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Moses+MA%22">Moses MA</searchLink>; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Lee+MJ%22">Lee MJ</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Yuno+A%22">Yuno A</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Lee+TD%22">Lee TD</searchLink>; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+T%22">Anderson T</searchLink>; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.<br /><searchLink fieldCode="AU" term="%22Kusewitt+D%22">Kusewitt D</searchLink>; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.<br /><searchLink fieldCode="AU" term="%22Hathaway+HH%22">Hathaway HH</searchLink>; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.<br /><searchLink fieldCode="AU" term="%22Jadhav+A%22">Jadhav A</searchLink>; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Picard+D%22">Picard D</searchLink>; Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland.<br /><searchLink fieldCode="AU" term="%22Trepel+JB%22">Trepel JB</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+JB%22">Mitchell JB</searchLink>; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Stott+GM%22">Stott GM</searchLink>; Leidos Biomedical, Frederick National Laboratory for Cancer Research, Frederick, MD 24060, USA.<br /><searchLink fieldCode="AU" term="%22Moore+W%22">Moore W</searchLink>; Leidos Biomedical, Frederick National Laboratory for Cancer Research, Frederick, MD 24060, USA.<br /><searchLink fieldCode="AU" term="%22Simeonov+A%22">Simeonov A</searchLink>; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Sklar+LA%22">Sklar LA</searchLink>; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.<br /><searchLink fieldCode="AU" term="%22Norenberg+JP%22">Norenberg JP</searchLink>; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.<br /><searchLink fieldCode="AU" term="%22Linehan+WM%22">Linehan WM</searchLink>; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Maloney+DJ%22">Maloney DJ</searchLink>; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Dang+CV%22">Dang CV</searchLink>; Ludwig Institute for Cancer Research, New York, NY 10017, USA; The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Waterson+AG%22">Waterson AG</searchLink>; Department of Chemistry, Vanderbilt University, Nashville, TN 37240, USA.<br /><searchLink fieldCode="AU" term="%22Hall+M%22">Hall M</searchLink>; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Darley-Usmar+VM%22">Darley-Usmar VM</searchLink>; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.<br /><searchLink fieldCode="AU" term="%22Krishna+MC%22">Krishna MC</searchLink>; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Neckers+LM%22">Neckers LM</searchLink>; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: neckersl@mail.nih.gov.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2020 Feb 11; Vol. 30 (6), pp. 1798-1810.e4.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101573691 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2211-1247 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Rep <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=32049011
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.celrep.2020.01.039
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1798
    Titles:
      – TitleFull: Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Oshima N
      – PersonEntity:
          Name:
            NameFull: Ishida R
      – PersonEntity:
          Name:
            NameFull: Kishimoto S
      – PersonEntity:
          Name:
            NameFull: Beebe K
      – PersonEntity:
          Name:
            NameFull: Brender JR
      – PersonEntity:
          Name:
            NameFull: Yamamoto K
      – PersonEntity:
          Name:
            NameFull: Urban D
      – PersonEntity:
          Name:
            NameFull: Rai G
      – PersonEntity:
          Name:
            NameFull: Johnson MS
      – PersonEntity:
          Name:
            NameFull: Benavides G
      – PersonEntity:
          Name:
            NameFull: Squadrito GL
      – PersonEntity:
          Name:
            NameFull: Crooks D
      – PersonEntity:
          Name:
            NameFull: Jackson J
      – PersonEntity:
          Name:
            NameFull: Joshi A
      – PersonEntity:
          Name:
            NameFull: Mott BT
      – PersonEntity:
          Name:
            NameFull: Shrimp JH
      – PersonEntity:
          Name:
            NameFull: Moses MA
      – PersonEntity:
          Name:
            NameFull: Lee MJ
      – PersonEntity:
          Name:
            NameFull: Yuno A
      – PersonEntity:
          Name:
            NameFull: Lee TD
      – PersonEntity:
          Name:
            NameFull: Hu X
      – PersonEntity:
          Name:
            NameFull: Anderson T
      – PersonEntity:
          Name:
            NameFull: Kusewitt D
      – PersonEntity:
          Name:
            NameFull: Hathaway HH
      – PersonEntity:
          Name:
            NameFull: Jadhav A
      – PersonEntity:
          Name:
            NameFull: Picard D
      – PersonEntity:
          Name:
            NameFull: Trepel JB
      – PersonEntity:
          Name:
            NameFull: Mitchell JB
      – PersonEntity:
          Name:
            NameFull: Stott GM
      – PersonEntity:
          Name:
            NameFull: Moore W
      – PersonEntity:
          Name:
            NameFull: Simeonov A
      – PersonEntity:
          Name:
            NameFull: Sklar LA
      – PersonEntity:
          Name:
            NameFull: Norenberg JP
      – PersonEntity:
          Name:
            NameFull: Linehan WM
      – PersonEntity:
          Name:
            NameFull: Maloney DJ
      – PersonEntity:
          Name:
            NameFull: Dang CV
      – PersonEntity:
          Name:
            NameFull: Waterson AG
      – PersonEntity:
          Name:
            NameFull: Hall M
      – PersonEntity:
          Name:
            NameFull: Darley-Usmar VM
      – PersonEntity:
          Name:
            NameFull: Krishna MC
      – PersonEntity:
          Name:
            NameFull: Neckers LM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 11
              M: 02
              Text: 2020 Feb 11
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-electronic
              Value: 2211-1247
          Numbering:
            – Type: volume
              Value: 30
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Cell reports
              Type: main
ResultId 1