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Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B.

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Title: Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B.
Authors: Xiao D; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: dong.xiao@merck.com., Dai X; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Liu H; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., He S; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Shi ZC; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Ludmerer SW; Department of Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Li F; Department of Drug Metabolism, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Nargund R; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Palani A; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Apr 01; Vol. 30 (7), pp. 127004. Date of Electronic Publication: 2020 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 32061500
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B.
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  Data: <searchLink fieldCode="AU" term="%22Xiao+D%22">Xiao D</searchLink>; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: dong.xiao@merck.com.<br /><searchLink fieldCode="AU" term="%22Dai+X%22">Dai X</searchLink>; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22He+S%22">He S</searchLink>; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Shi+ZC%22">Shi ZC</searchLink>; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Ludmerer+SW%22">Ludmerer SW</searchLink>; Department of Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA.<br /><searchLink fieldCode="AU" term="%22Li+F%22">Li F</searchLink>; Department of Drug Metabolism, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Nargund+R%22">Nargund R</searchLink>; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Palani+A%22">Palani A</searchLink>; Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2020 Apr 01; Vol. 30 (7), pp. 127004. <i>Date of Electronic Publication: </i>2020 Feb 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bmcl.2020.127004
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        Text: English
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        StartPage: 127004
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      – TitleFull: Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B.
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              Text: 2020 Apr 01
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              Y: 2020
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