Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients.

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Title: Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients.
Authors: Olsen HT; From the Departments of Anesthesiology and Intensive Care, Odense University Hospital-Svendborg Hospital, Svendborg (H.T.O.), the Departments of Clinical Research (H.T.O., H.K.N., T.S., J.O., P.T.) and Business and Economics (S.K., J.T.L.), University of Southern Denmark, and the Department of Anesthesiology and Intensive Care, Odense University Hospital (T.S., P.T.), Odense, the Department of Anesthesiology and Intensive Care, Hospital Lillebaelt, Kolding (H.K.N.), and the Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg (J.O.) - all in Denmark; the Department of Anesthesiology and Intensive Care, Vestfold Hospital, Tønsberg (K.-A.W.), and the Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø (L.M.Y., B.A.K.) - both in Norway; and the Department of Anesthesiology and Intensive Care, Linköping University Hospital, Linköping, Sweden (M.C.)., Nedergaard HK; From the Departments of Anesthesiology and Intensive Care, Odense University Hospital-Svendborg Hospital, Svendborg (H.T.O.), the Departments of Clinical Research (H.T.O., H.K.N., T.S., J.O., P.T.) and Business and Economics (S.K., J.T.L.), University of Southern Denmark, and the Department of Anesthesiology and Intensive Care, Odense University Hospital (T.S., P.T.), Odense, the Department of Anesthesiology and Intensive Care, Hospital Lillebaelt, Kolding (H.K.N.), and the Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg (J.O.) - all in Denmark; the Department of Anesthesiology and Intensive Care, Vestfold Hospital, Tønsberg (K.-A.W.), and the Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø (L.M.Y., B.A.K.) - both in Norway; and the Department of Anesthesiology and Intensive Care, Linköping University Hospital, Linköping, Sweden (M.C.)., Strøm T; From the Departments of Anesthesiology and Intensive Care, Odense University Hospital-Svendborg Hospital, Svendborg (H.T.O.), the Departments of Clinical Research (H.T.O., H.K.N., T.S., J.O., P.T.) and Business and Economics (S.K., J.T.L.), University of Southern Denmark, and the Department of Anesthesiology and Intensive Care, Odense University Hospital (T.S., P.T.), Odense, the Department of Anesthesiology and Intensive Care, Hospital Lillebaelt, Kolding (H.K.N.), and the Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg (J.O.) - all in Denmark; the Department of Anesthesiology and Intensive Care, Vestfold Hospital, Tønsberg (K.-A.W.), and the Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø (L.M.Y., B.A.K.) - both in Norway; and the Department of Anesthesiology and Intensive Care, Linköping University Hospital, Linköping, Sweden (M.C.)., Oxlund J; From the Departments of Anesthesiology and Intensive Care, Odense University Hospital-Svendborg Hospital, Svendborg (H.T.O.), the Departments of Clinical Research (H.T.O., H.K.N., T.S., J.O., P.T.) and Business and Economics (S.K., J.T.L.), University of Southern Denmark, and the Department of Anesthesiology and Intensive Care, Odense University Hospital (T.S., P.T.), Odense, the Department of Anesthesiology and Intensive Care, Hospital Lillebaelt, Kolding (H.K.N.), and the Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg (J.O.) - all in Denmark; the Department of Anesthesiology and Intensive Care, Vestfold Hospital, Tønsberg (K.-A.W.), and the Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø (L.M.Y., B.A.K.) - both in Norway; and the Department of Anesthesiology and Intensive Care, Linköping University Hospital, Linköping, Sweden (M.C.)., Wian KA; From the Departments of Anesthesiology and Intensive Care, Odense University Hospital-Svendborg Hospital, Svendborg (H.T.O.), the Departments of Clinical Research (H.T.O., H.K.N., T.S., J.O., P.T.) and Business and Economics (S.K., J.T.L.), University of Southern Denmark, and the Department of Anesthesiology and Intensive Care, Odense University Hospital (T.S., P.T.), Odense, the Department of Anesthesiology and Intensive Care, Hospital Lillebaelt, Kolding (H.K.N.), and the Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg (J.O.) - all in Denmark; the Department of Anesthesiology and Intensive Care, Vestfold Hospital, Tønsberg (K.-A.W.), and the Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø (L.M.Y., B.A.K.) - both in Norway; and the Department of Anesthesiology and Intensive Care, Linköping University Hospital, Linköping, Sweden (M.C.)., Ytrebø LM; From the Departments of Anesthesiology and Intensive Care, Odense University Hospital-Svendborg Hospital, Svendborg (H.T.O.), the Departments of Clinical Research (H.T.O., H.K.N., T.S., J.O., P.T.) and Business and Economics (S.K., J.T.L.), University of Southern Denmark, and the Department of Anesthesiology and Intensive Care, Odense University Hospital (T.S., P.T.), Odense, the Department of Anesthesiology and Intensive Care, Hospital Lillebaelt, Kolding (H.K.N.), and the Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg (J.O.) - all in Denmark; the Department of Anesthesiology and Intensive Care, Vestfold Hospital, Tønsberg (K.-A.W.), and the Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø (L.M.Y., B.A.K.) - both in Norway; and the Department of Anesthesiology and Intensive Care, Linköping University Hospital, Linköping, Sweden (M.C.)., Kroken BA; From the Departments of Anesthesiology and Intensive Care, Odense University Hospital-Svendborg Hospital, Svendborg (H.T.O.), the Departments of Clinical Research (H.T.O., H.K.N., T.S., J.O., P.T.) and Business and Economics (S.K., J.T.L.), University of Southern Denmark, and the Department of Anesthesiology and Intensive Care, Odense University Hospital (T.S., P.T.), Odense, the Department of Anesthesiology and Intensive Care, Hospital Lillebaelt, Kolding (H.K.N.), and the Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg (J.O.) - all in Denmark; the Department of Anesthesiology and Intensive Care, Vestfold Hospital, Tønsberg (K.-A.W.), and the Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø (L.M.Y., B.A.K.) - both in Norway; and the Department of Anesthesiology and Intensive Care, Linköping University Hospital, Linköping, Sweden (M.C.)., Chew M; From the Departments of Anesthesiology and Intensive Care, Odense University Hospital-Svendborg Hospital, Svendborg (H.T.O.), the Departments of Clinical Research (H.T.O., H.K.N., T.S., J.O., P.T.) and Business and Economics (S.K., J.T.L.), University of Southern Denmark, and the Department of Anesthesiology and Intensive Care, Odense University Hospital (T.S., P.T.), Odense, the Department of Anesthesiology and Intensive Care, Hospital Lillebaelt, Kolding (H.K.N.), and the Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg (J.O.) - all in Denmark; the Department of Anesthesiology and Intensive Care, Vestfold Hospital, Tønsberg (K.-A.W.), and the Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø (L.M.Y., B.A.K.) - both in Norway; and the Department of Anesthesiology and Intensive Care, Linköping University Hospital, Linköping, Sweden (M.C.)., Korkmaz S; From the Departments of Anesthesiology and Intensive Care, Odense University Hospital-Svendborg Hospital, Svendborg (H.T.O.), the Departments of Clinical Research (H.T.O., H.K.N., T.S., J.O., P.T.) and Business and Economics (S.K., J.T.L.), University of Southern Denmark, and the Department of Anesthesiology and Intensive Care, Odense University Hospital (T.S., P.T.), Odense, the Department of Anesthesiology and Intensive Care, Hospital Lillebaelt, Kolding (H.K.N.), and the Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg (J.O.) - all in Denmark; the Department of Anesthesiology and Intensive Care, Vestfold Hospital, Tønsberg (K.-A.W.), and the Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø (L.M.Y., B.A.K.) - both in Norway; and the Department of Anesthesiology and Intensive Care, Linköping University Hospital, Linköping, Sweden (M.C.)., Lauridsen JT; From the Departments of Anesthesiology and Intensive Care, Odense University Hospital-Svendborg Hospital, Svendborg (H.T.O.), the Departments of Clinical Research (H.T.O., H.K.N., T.S., J.O., P.T.) and Business and Economics (S.K., J.T.L.), University of Southern Denmark, and the Department of Anesthesiology and Intensive Care, Odense University Hospital (T.S., P.T.), Odense, the Department of Anesthesiology and Intensive Care, Hospital Lillebaelt, Kolding (H.K.N.), and the Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg (J.O.) - all in Denmark; the Department of Anesthesiology and Intensive Care, Vestfold Hospital, Tønsberg (K.-A.W.), and the Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø (L.M.Y., B.A.K.) - both in Norway; and the Department of Anesthesiology and Intensive Care, Linköping University Hospital, Linköping, Sweden (M.C.)., Toft P; From the Departments of Anesthesiology and Intensive Care, Odense University Hospital-Svendborg Hospital, Svendborg (H.T.O.), the Departments of Clinical Research (H.T.O., H.K.N., T.S., J.O., P.T.) and Business and Economics (S.K., J.T.L.), University of Southern Denmark, and the Department of Anesthesiology and Intensive Care, Odense University Hospital (T.S., P.T.), Odense, the Department of Anesthesiology and Intensive Care, Hospital Lillebaelt, Kolding (H.K.N.), and the Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg (J.O.) - all in Denmark; the Department of Anesthesiology and Intensive Care, Vestfold Hospital, Tønsberg (K.-A.W.), and the Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø (L.M.Y., B.A.K.) - both in Norway; and the Department of Anesthesiology and Intensive Care, Linköping University Hospital, Linköping, Sweden (M.C.).
Source: The New England journal of medicine [N Engl J Med] 2020 Mar 19; Vol. 382 (12), pp. 1103-1111. Date of Electronic Publication: 2020 Feb 16.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1533-4406
DOI:10.1056/NEJMoa1906759