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Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease.

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Title: Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease.
Authors: Mosley JD; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee., Gupta DK; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Tan J; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California., Yao J; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California., Wells QS; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee., Shaffer CM; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Kundu S; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Robinson-Cohen C; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Vanderbilt O'Brien Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, Tennessee., Psaty BM; Departments of Medicine, Epidemiology and Health Services, University of Washington School of Public Health; and Kaiser Permanente Washington Health Research Institute, Seattle, Washington., Rich SS; Department of Public Health Sciences, Center for Public Health Genomics, Charlottesville, Virginia., Post WS; Department of Medicine, Johns Hopkins University, Baltimore, Maryland.; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland., Guo X; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California., Rotter JI; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California.; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Medicine, Torrance, California12., Roden DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee., Gerszten RE; Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts., Wang TJ; Department of Internal Medicine, University of Texas Southwestern Medical Center.
Source: JAMA [JAMA] 2020 Feb 18; Vol. 323 (7), pp. 627-635.
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease.
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  Data: <searchLink fieldCode="AU" term="%22Mosley+JD%22">Mosley JD</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Gupta+DK%22">Gupta DK</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Tan+J%22">Tan J</searchLink>; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California.<br /><searchLink fieldCode="AU" term="%22Yao+J%22">Yao J</searchLink>; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California.<br /><searchLink fieldCode="AU" term="%22Wells+QS%22">Wells QS</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Shaffer+CM%22">Shaffer CM</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Kundu+S%22">Kundu S</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Robinson-Cohen+C%22">Robinson-Cohen C</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Vanderbilt O'Brien Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Psaty+BM%22">Psaty BM</searchLink>; Departments of Medicine, Epidemiology and Health Services, University of Washington School of Public Health; and Kaiser Permanente Washington Health Research Institute, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Rich+SS%22">Rich SS</searchLink>; Department of Public Health Sciences, Center for Public Health Genomics, Charlottesville, Virginia.<br /><searchLink fieldCode="AU" term="%22Post+WS%22">Post WS</searchLink>; Department of Medicine, Johns Hopkins University, Baltimore, Maryland.; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California.; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Medicine, Torrance, California12.<br /><searchLink fieldCode="AU" term="%22Roden+DM%22">Roden DM</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Gerszten+RE%22">Gerszten RE</searchLink>; Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Wang+TJ%22">Wang TJ</searchLink>; Department of Internal Medicine, University of Texas Southwestern Medical Center.
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