Epigenetic therapy inhibits metastases by disrupting premetastatic niches.

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Title: Epigenetic therapy inhibits metastases by disrupting premetastatic niches.
Authors: Lu Z; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Zou J; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Li S; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Topper MJ; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Tao Y; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Zhang H; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Jiao X; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Xie W; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Kong X; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Vaz M; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Li H; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Cai Y; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Xia L; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, China., Huang P; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Rodgers K; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lee B; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Riemer JB; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Day CP; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Yen RC; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Cui Y; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Wang Y; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Wang Y; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Zhang W; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Thoracic Surgery, The Seventh Medical Center of PLA General Hospital, Beijing, China., Easwaran H; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Hulbert A; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Surgery, University of Illinois College of Medicine, Chicago, IL, USA., Kim K; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Juergens RA; Division of Medical Oncology, McMaster University, Juravinski Cancer Centre, Hamilton, Ontario, Canada., Yang SC; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Battafarano RJ; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bush EL; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Broderick SR; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cattaneo SM; Department of Surgery, Anne Arundel Medical Center, Annapolis, MD, USA., Brahmer JR; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Rudin CM; Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wrangle J; Division of Hematology-Oncology, Medical University of South Carolina, Charleston, SC, USA., Mei Y; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Kim YJ; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University, Nashville, TN, USA., Zhang B; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA.; School of Biomedical Engineering, Dalian University of Technology, Dalian, China., Wang KK; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA., Forde PM; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Margolick JB; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Nelkin BD; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Zahnow CA; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Pardoll DM; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Housseau F; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA. fhousse1@jhmi.edu.; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA. fhousse1@jhmi.edu., Baylin SB; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA. sbaylin@jhmi.edu., Shen L; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China. shenlin@bjmu.edu.cn., Brock MV; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. mabrock@jhmi.edu.; Department of Oncology, The Johns Hopkins School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA. mabrock@jhmi.edu.
Source: Nature [Nature] 2020 Mar; Vol. 579 (7798), pp. 284-290. Date of Electronic Publication: 2020 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-020-2054-x