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Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation.

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Title: Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation.
Authors: Jones M; Signalling and Structural Biology Laboratory, Francis Crick Institute, NW1 1AT, London, UK., Beuron F; Structural Electron Microscopy, The Institute of Cancer Research, SW7 3RP, London, UK., Borg A; Mass Spectrometry Science Technology Platform, Francis Crick Institute, NW1 1AT, London, UK., Nans A; Structural Biology of Cells and Viruses, Francis Crick Institute, NW1 1AT, London, UK., Earl CP; Signalling and Structural Biology Laboratory, Francis Crick Institute, NW1 1AT, London, UK., Briggs DC; Signalling and Structural Biology Laboratory, Francis Crick Institute, NW1 1AT, London, UK., Snijders AP; Mass Spectrometry Science Technology Platform, Francis Crick Institute, NW1 1AT, London, UK., Bowles M; Signalling and Structural Biology Laboratory, Francis Crick Institute, NW1 1AT, London, UK., Morris EP; Structural Electron Microscopy, The Institute of Cancer Research, SW7 3RP, London, UK., Linch M; Department of Oncology, University College London Cancer Institute, WC1E 6AG, London, England, UK., McDonald NQ; Signalling and Structural Biology Laboratory, Francis Crick Institute, NW1 1AT, London, UK. neil.mcdonald@crick.ac.uk.; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, Malet Street, London, WC1E 7HX, UK. neil.mcdonald@crick.ac.uk.
Source: Nature communications [Nat Commun] 2020 Feb 28; Vol. 11 (1), pp. 1120. Date of Electronic Publication: 2020 Feb 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2020 Feb 28; Vol. 11 (1), pp. 1120. <i>Date of Electronic Publication: </i>2020 Feb 28.
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