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Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy.

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Title: Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy.
Authors: Chuang SH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Lee YE; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Huang LYL; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan., Chen CK; Genomics Research Center, Academia Sinica, Taipei City, Taiwan., Lai CL; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Lin YH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Yang JY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Yang SC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Chang LH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Chen CH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Liu CW; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Lin HS; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Lee YR; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Huang KP; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Fu KC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Jen HM; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Lai JY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan., Jian PS; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan., Wang YC; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan., Hsueh WY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan., Tsai PY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Hong WH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Chang CC; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan., Wu DZ; Xenobiotic Laboratories, Inc., Plainsboro, NJ, USA., Wu J; Xenobiotic Laboratories, Inc., Plainsboro, NJ, USA., Chen MH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Yu KM; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan., Chern CY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan., Chang JM; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan., Lau JYN; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan., Huang JJ; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan. Electronic address: lukehuang@mail.ncyu.edu.tw.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2020 Apr 01; Vol. 191, pp. 112118. Date of Electronic Publication: 2020 Feb 07.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
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  Data: Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy.
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  Data: <searchLink fieldCode="AU" term="%22Chuang+SH%22">Chuang SH</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+YE%22">Lee YE</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+LYL%22">Huang LYL</searchLink>; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CK%22">Chen CK</searchLink>; Genomics Research Center, Academia Sinica, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+CL%22">Lai CL</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YH%22">Lin YH</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+JY%22">Yang JY</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+SC%22">Yang SC</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+LH%22">Chang LH</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+CW%22">Liu CW</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HS%22">Lin HS</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+YR%22">Lee YR</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+KP%22">Huang KP</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fu+KC%22">Fu KC</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jen+HM%22">Jen HM</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+JY%22">Lai JY</searchLink>; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jian+PS%22">Jian PS</searchLink>; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+YC%22">Wang YC</searchLink>; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsueh+WY%22">Hsueh WY</searchLink>; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+PY%22">Tsai PY</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hong+WH%22">Hong WH</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CC%22">Chang CC</searchLink>; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+DZ%22">Wu DZ</searchLink>; Xenobiotic Laboratories, Inc., Plainsboro, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Xenobiotic Laboratories, Inc., Plainsboro, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Chen+MH%22">Chen MH</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+KM%22">Yu KM</searchLink>; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chern+CY%22">Chern CY</searchLink>; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+JM%22">Chang JM</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lau+JYN%22">Lau JYN</searchLink>; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+JJ%22">Huang JJ</searchLink>; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan. Electronic address: lukehuang@mail.ncyu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2020 Apr 01; Vol. 191, pp. 112118. <i>Date of Electronic Publication: </i>2020 Feb 07.
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