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Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development

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Title: Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
Authors: Marx U; TissUse GmbH, Berlin, Germany.; Technische Universitaet Berlin, Germany., Akabane T; Stem Cell Evaluation Technology Research Association, Tokyo, Japan., Andersson TB; DMPK, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Baker E; Physicians Committee for Responsible Medicine, Washington DC, USA., Beilmann M; Boehringer Ingelheim Pharma GmbH & Co. KG, Non-clinical Drug Safety, Biberach, Germany., Beken S; Federal Agency for Medicines and Health Products, Brussels, Belgium., Brendler-Schwaab S; BfArM, Bonn, Germany., Cirit M; Javelin Biotech, Inc, Woburn, MA, USA., David R; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK, Dehne EM; TissUse GmbH, Berlin, Germany., Durieux I; TissUse GmbH, Berlin, Germany., Ewart L; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK, Fitzpatrick SC; US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA., Frey O; InSphero, Schlieren, Switzerland., Fuchs F; Novartis Institutes for BioMedical Research Chemical Biology & Therapeutics, Basel, Switzerland., Griffith LG; Massachusetts Institute of Technology, Cambridge, MA, USA., Hamilton GA; Emulate Inc., Boston, USA., Hartung T; Center for Alternatives to Animal Testing, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.; Center for Alternatives to Animal Testing-Europe, University of Konstanz, Konstanz, Germany.; AxoSim, Inc., New Orleans, LA, USA, Hoeng J; Philip Morris International R&D, Neuchâtel, Switzerland., Hogberg H; Center for Alternatives to Animal Testing, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Hughes DJ; CN Bio Innovations Ltd., Welwyn Garden City, UK., Ingber DE; Wyss Institute for Biology Inspired Engineering, Harvard University, Boston, USA., Iskandar A; Philip Morris International R&D, Neuchâtel, Switzerland., Kanamori T; National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan., Kojima H; Japanese Center for Validation of Animal Methods, Tokyo, Japan., Kuehnl J; Beiersdorf, Hamburg, Germany., Leist M; Center for Alternatives to Animal Testing-Europe, University of Konstanz, Konstanz, Germany., Li B; National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Beijing, P.R. China., Loskill P; Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany.; Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany., Mendrick DL; National Center for Toxicological Research, FDA, Silver Spring, MD, USA., Neumann T; Nortis Inc., Seattle WA, USA., Pallocca G; Center for Alternatives to Animal Testing-Europe, University of Konstanz, Konstanz, Germany., Rusyn I; Texas A&M University, College Station, TX, USA., Smirnova L; Center for Alternatives to Animal Testing, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Steger-Hartmann T; Bayer, Investigational Toxicology, Berlin, Germany., Tagle DA; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA., Tonevitsky A; M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia.; National Research University Higher School of Economics, Russia., Tsyb S; Russian Ministry of Production and Trade, Moscow, Russia., Trapecar M; Massachusetts Institute of Technology, Cambridge, MA, USA., Van de Water B; Universiteit Leiden, Leiden, The Netherlands., Van den Eijnden-van Raaij J; Institute for Human Organ and Disease Model Technologies, Eindhoven, The Netherlands., Vulto P; MIMETAS BV, Leiden, The Netherlands., Watanabe K; Daiichi Sankyo Co., Ltd., Tokyo, Japan., Wolf A; InSphero, Schlieren, Switzerland., Zhou X; National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Beijing, P.R. China., Roth A; F. Hoffmann-La Roche Ltd, Roche Innovation Center Basel, Switzerland.
Source: ALTEX [ALTEX] 2020; Vol. 37 (3), pp. 365-394. Date of Electronic Publication: 2020 Feb 28.
Publication Type: Journal Article
Journal Info: Publisher: Spektrum Akademischer Verlag Country of Publication: Germany NLM ID: 100953980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-8551 (Electronic) Linking ISSN: 1868596X NLM ISO Abbreviation: ALTEX Subsets: MEDLINE
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