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Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS.

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Title: Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS.
Authors: Goodwin MS; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Croft CL; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Futch HS; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Ryu D; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Ceballos-Diaz C; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Liu X; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Paterno G; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Mejia C; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Deng D; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Menezes K; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Londono L; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Arjona K; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Parianos M; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Truong V; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Rostonics E; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Hernandez A; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA., Boye SL; Department of Pediatrics and the Powell Gene Therapy Center, University of Florida, Gainesville, Florida, USA., Boye SE; Department of Ophthalmology, University of Florida, Gainesville, Florida, USA., Levites Y; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida, USA., Cruz PE; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA. pecruz68@ufl.edu.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA. pecruz68@ufl.edu., Golde TE; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA. tgolde@ufl.edu.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA. tgolde@ufl.edu.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida, USA. tgolde@ufl.edu.
Source: Molecular neurodegeneration [Mol Neurodegener] 2020 Mar 02; Vol. 15 (1), pp. 15. Date of Electronic Publication: 2020 Mar 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1750-1326
DOI:10.1186/s13024-020-00361-z