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The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques.

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Title: The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques.
Authors: Webb GM; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Molden J; Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America., Busman-Sahay K; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Abdulhaqq S; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Wu HL; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Weber WC; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Bateman KB; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Reed JS; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Northrup M; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Maier N; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Tanaka S; ImmunityBio, Los Angeles, California, United States of America., Gao L; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Davey B; Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America., Carpenter BL; Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America., Axthelm MK; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America., Stanton JJ; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Smedley J; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Greene JM; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Safrit JT; NantKWest, Los Angeles, California, United States of America., Estes JD; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Skinner PJ; Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America., Sacha JB; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Source: PLoS pathogens [PLoS Pathog] 2020 Mar 12; Vol. 16 (3), pp. e1008339. Date of Electronic Publication: 2020 Mar 12 (Print Publication: 2020).
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
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  Data: The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques.
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