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PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment.

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Title: PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment.
Authors: Kleineidam L; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Chouraki V; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de risque Et déterminants moléculaires des maladies liées au vieillissement, Lille, France.; Epidemiology and Public Health Department, Centre Hospitalier Universitaire de Lille, Lille, France., Próchnicki T; Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany., van der Lee SJ; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Genetics, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Madrid-Márquez L; Andalusian Bioinformatics Research Centre (CAEBi), Seville, Spain., Wagner-Thelen H; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany., Karaca I; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Weinhold L; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany., Wolfsgruber S; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Boland A; Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, Évry, France., Martino Adami PV; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany., Lewczuk P; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Neurodegeneration Diagnostics, Medical University of Białystok, Białystok, Poland.; Department of Biochemical Diagnostics, University Hospital of Białystok, Białystok, Poland., Popp J; Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zurich, Zurich, Switzerland., Brosseron F; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Jansen IE; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Hulsman M; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Genetics, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Kornhuber J; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany., Peters O; Department of Psychiatry, Charité - Universitätsmedizin Berlin, Berlin, Germany.; DZNE, German Center for Neurodegenerative Diseases, Berlin, Germany., Berr C; INSERM, University Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France., Heun R; Department of Psychiatry and Psychotherapy, University Hospital Bonn, 53127, Bonn, Germany., Frölich L; Department of Geriatric Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany., Tzourio C; Inserm, Bordeaux Population Health Research Center, UMR1219, University of Bordeaux, Bordeaux, France., Dartigues JF; Inserm, Bordeaux Population Health Research Center, UMR1219, University of Bordeaux, Bordeaux, France., Hüll M; Department of Psychiatry and Psychotherapy, Center for Psychiatry, Clinic for Geriatric Psychiatry and Psychotherapy Emmendingen, University of Freiburg, Freiburg, Germany., Espinosa A; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Hernández I; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., de Rojas I; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Orellana A; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain., Valero S; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Stringa N; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC-Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., van Schoor NM; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC-Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Huisman M; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC-Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Scheltens P; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Rüther E; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Deleuze JF; Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, Évry, France., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; iBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal., Tarraga L; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Schmid M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany., Scherer M; Department of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Heneka MT; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Amouyel P; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de risque Et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany., Boada M; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Maier W; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Schneider A; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., González-Pérez A; Andalusian Bioinformatics Research Centre (CAEBi), Seville, Spain., van der Flier WM; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Wagner M; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Lambert JC; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de risque Et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Holstege H; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Genetics, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Sáez ME; Andalusian Bioinformatics Research Centre (CAEBi), Seville, Spain., Latz E; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany.; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.; Centre for Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology, Trondheim, Norway., Ruiz A; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Ramirez A; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany. alfredo.ramirez@uk-koeln.de.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany. alfredo.ramirez@uk-koeln.de.
Corporate Authors: Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Source: Acta neuropathologica [Acta Neuropathol] 2020 Jun; Vol. 139 (6), pp. 1025-1044. Date of Electronic Publication: 2020 Mar 12.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Kleineidam+L%22">Kleineidam L</searchLink>; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Chouraki+V%22">Chouraki V</searchLink>; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de risque Et déterminants moléculaires des maladies liées au vieillissement, Lille, France.; Epidemiology and Public Health Department, Centre Hospitalier Universitaire de Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Próchnicki+T%22">Próchnicki T</searchLink>; Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22van+der+Lee+SJ%22">van der Lee SJ</searchLink>; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Genetics, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Madrid-Márquez+L%22">Madrid-Márquez L</searchLink>; Andalusian Bioinformatics Research Centre (CAEBi), Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Wagner-Thelen+H%22">Wagner-Thelen H</searchLink>; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Karaca+I%22">Karaca I</searchLink>; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Weinhold+L%22">Weinhold L</searchLink>; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wolfsgruber+S%22">Wolfsgruber S</searchLink>; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Boland+A%22">Boland A</searchLink>; Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, Évry, France.<br /><searchLink fieldCode="AU" term="%22Martino+Adami+PV%22">Martino Adami PV</searchLink>; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Lewczuk+P%22">Lewczuk P</searchLink>; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Neurodegeneration Diagnostics, Medical University of Białystok, Białystok, Poland.; Department of Biochemical Diagnostics, University Hospital of Białystok, Białystok, Poland.<br /><searchLink fieldCode="AU" term="%22Popp+J%22">Popp J</searchLink>; Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Brosseron+F%22">Brosseron F</searchLink>; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Jansen+IE%22">Jansen IE</searchLink>; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hulsman+M%22">Hulsman M</searchLink>; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Genetics, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kornhuber+J%22">Kornhuber J</searchLink>; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Peters+O%22">Peters O</searchLink>; Department of Psychiatry, Charité - Universitätsmedizin Berlin, Berlin, Germany.; DZNE, German Center for Neurodegenerative Diseases, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Berr+C%22">Berr C</searchLink>; INSERM, University Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Heun+R%22">Heun R</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital Bonn, 53127, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Frölich+L%22">Frölich L</searchLink>; Department of Geriatric Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Tzourio+C%22">Tzourio C</searchLink>; Inserm, Bordeaux Population Health Research Center, UMR1219, University of Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Dartigues+JF%22">Dartigues JF</searchLink>; Inserm, Bordeaux Population Health Research Center, UMR1219, University of Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Hüll+M%22">Hüll M</searchLink>; Department of Psychiatry and Psychotherapy, Center for Psychiatry, Clinic for Geriatric Psychiatry and Psychotherapy Emmendingen, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Espinosa+A%22">Espinosa A</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Hernández+I%22">Hernández I</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22de+Rojas+I%22">de Rojas I</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Orellana+A%22">Orellana A</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Valero+S%22">Valero S</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Stringa+N%22">Stringa N</searchLink>; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC-Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Schoor+NM%22">van Schoor NM</searchLink>; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC-Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Huisman+M%22">Huisman M</searchLink>; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC-Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Scheltens+P%22">Scheltens P</searchLink>; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rüther+E%22">Rüther E</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Deleuze+JF%22">Deleuze JF</searchLink>; Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, Évry, France.<br /><searchLink fieldCode="AU" term="%22Wiltfang+J%22">Wiltfang J</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; iBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Tarraga+L%22">Tarraga L</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Schmid+M%22">Schmid M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Scherer+M%22">Scherer M</searchLink>; Department of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Riedel-Heller+S%22">Riedel-Heller S</searchLink>; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Heneka+MT%22">Heneka MT</searchLink>; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Amouyel+P%22">Amouyel P</searchLink>; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de risque Et déterminants moléculaires des maladies liées au vieillissement, Lille, France.<br /><searchLink fieldCode="AU" term="%22Jessen+F%22">Jessen F</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Boada+M%22">Boada M</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Maier+W%22">Maier W</searchLink>; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+A%22">Schneider A</searchLink>; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22González-Pérez+A%22">González-Pérez A</searchLink>; Andalusian Bioinformatics Research Centre (CAEBi), Seville, Spain.<br /><searchLink fieldCode="AU" term="%22van+der+Flier+WM%22">van der Flier WM</searchLink>; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wagner+M%22">Wagner M</searchLink>; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Lambert+JC%22">Lambert JC</searchLink>; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de risque Et déterminants moléculaires des maladies liées au vieillissement, Lille, France.<br /><searchLink fieldCode="AU" term="%22Holstege+H%22">Holstege H</searchLink>; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Genetics, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sáez+ME%22">Sáez ME</searchLink>; Andalusian Bioinformatics Research Centre (CAEBi), Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Latz+E%22">Latz E</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany.; Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.; Centre for Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Ruiz+A%22">Ruiz A</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ramirez+A%22">Ramirez A</searchLink>; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany. alfredo.ramirez@uk-koeln.de.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany. alfredo.ramirez@uk-koeln.de.
– Name: AuthorCorporate
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  Data: <searchLink fieldCode="CA" term="%22Alzheimer%27s+Disease+Neuroimaging+Initiative+%28ADNI%29%22">Alzheimer’s Disease Neuroimaging Initiative (ADNI)</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2020 Jun; Vol. 139 (6), pp. 1025-1044. <i>Date of Electronic Publication: </i>2020 Mar 12.
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  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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        Value: 10.1007/s00401-020-02138-6
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      – TitleFull: PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment.
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            – D: 01
              M: 06
              Text: 2020 Jun
              Type: published
              Y: 2020
          Identifiers:
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              Value: 1432-0533
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          Titles:
            – TitleFull: Acta neuropathologica
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