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MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice.

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Title: MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice.
Authors: Healy ME; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Boege Y; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Hodder MC; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK. Electronic address: achim.weber@usz.ch., Böhm F; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Malehmir M; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Scherr AL; National Center for Tumor Diseases, Department of Medical Oncology and Heidelberg University Hospital, Internal Medicine VI, Heidelberg, Germany., Jetzer J; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Chan LK; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Parrotta R; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Jacobs K; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Clerbaux LA; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Kreutzer S; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Campbell A; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK., Gilchrist E; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK., Gilroy K; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK., Rodewald AK; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Honcharova-Biletska H; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Schimmer R; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Vélez K; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Büeler S; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Cammareri P; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK., Kalna G; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK., Wenning AS; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland., McCoy KD; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland; Department of Physiology and Pharmacology and Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Gomez de Agüero M; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland., Schulze-Bergkamen H; National Center for Tumor Diseases, Department of Medical Oncology and Heidelberg University Hospital, Internal Medicine VI, Heidelberg, Germany., Klose CSN; Institute of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Germany., Unger K; Research Unit of Radiation Cytogenetics, Helmholtz Zentrum München, Neuherberg Germany., Macpherson AJ; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland., Moor AE; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Köhler B; National Center for Tumor Diseases, Department of Medical Oncology and Heidelberg University Hospital, Internal Medicine VI, Heidelberg, Germany., Sansom OJ; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK. Electronic address: o.sansom@beatson.gla.ac.uk., Heikenwälder M; Division of Chronic Inflammation and Cancer, Deutsches Krebs-Forschungszentrum (DKFZ), Heidelberg, Germany. Electronic address: m.heikenwaelder@dkfz.de., Weber A; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland. Electronic address: achim.weber@usz.ch.
Source: Gastroenterology [Gastroenterology] 2020 Jul; Vol. 159 (1), pp. 183-199. Date of Electronic Publication: 2020 Mar 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
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  Data: MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice.
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Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jacobs+K%22">Jacobs K</searchLink>; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Clerbaux+LA%22">Clerbaux LA</searchLink>; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kreutzer+S%22">Kreutzer S</searchLink>; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Campbell+A%22">Campbell A</searchLink>; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Gilchrist+E%22">Gilchrist E</searchLink>; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Gilroy+K%22">Gilroy K</searchLink>; 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Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Kalna+G%22">Kalna G</searchLink>; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Wenning+AS%22">Wenning AS</searchLink>; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22McCoy+KD%22">McCoy KD</searchLink>; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland; Department of Physiology and Pharmacology and Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Gomez+de+Agüero+M%22">Gomez de Agüero M</searchLink>; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schulze-Bergkamen+H%22">Schulze-Bergkamen H</searchLink>; National Center for Tumor Diseases, Department of Medical Oncology and Heidelberg University Hospital, Internal Medicine VI, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Klose+CSN%22">Klose CSN</searchLink>; Institute of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Unger+K%22">Unger K</searchLink>; Research Unit of Radiation Cytogenetics, Helmholtz Zentrum München, Neuherberg Germany.<br /><searchLink fieldCode="AU" term="%22Macpherson+AJ%22">Macpherson AJ</searchLink>; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Moor+AE%22">Moor AE</searchLink>; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Köhler+B%22">Köhler B</searchLink>; National Center for Tumor Diseases, Department of Medical Oncology and Heidelberg University Hospital, Internal Medicine VI, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sansom+OJ%22">Sansom OJ</searchLink>; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK. Electronic address: o.sansom@beatson.gla.ac.uk.<br /><searchLink fieldCode="AU" term="%22Heikenwälder+M%22">Heikenwälder M</searchLink>; Division of Chronic Inflammation and Cancer, Deutsches Krebs-Forschungszentrum (DKFZ), Heidelberg, Germany. Electronic address: m.heikenwaelder@dkfz.de.<br /><searchLink fieldCode="AU" term="%22Weber+A%22">Weber A</searchLink>; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland. Electronic address: achim.weber@usz.ch.
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