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Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.

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Title: Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.
Authors: Yin L; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America., Masuyer G; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Zhang S; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America., Zhang J; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America., Miyashita SI; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America., Burgin D; Ipsen Bioinnovation, Abingdon, United Kingdom., Lovelock L; Ipsen Bioinnovation, Abingdon, United Kingdom., Coker SF; Ipsen Bioinnovation, Abingdon, United Kingdom., Fu TM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, United States of America., Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden., Dong M; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America.
Source: PLoS biology [PLoS Biol] 2020 Mar 17; Vol. 18 (3), pp. e3000618. Date of Electronic Publication: 2020 Mar 17 (Print Publication: 2020).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Yin+L%22">Yin L</searchLink>; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Masuyer+G%22">Masuyer G</searchLink>; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Miyashita+SI%22">Miyashita SI</searchLink>; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Burgin+D%22">Burgin D</searchLink>; Ipsen Bioinnovation, Abingdon, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lovelock+L%22">Lovelock L</searchLink>; Ipsen Bioinnovation, Abingdon, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Coker+SF%22">Coker SF</searchLink>; Ipsen Bioinnovation, Abingdon, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fu+TM%22">Fu TM</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Stenmark+P%22">Stenmark P</searchLink>; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Dong+M%22">Dong M</searchLink>; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America.
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  Data: <searchLink fieldCode="JN" term="%22101183755%22">PLoS biology</searchLink> [PLoS Biol] 2020 Mar 17; Vol. 18 (3), pp. e3000618. <i>Date of Electronic Publication: </i>2020 Mar 17 (<i>Print Publication: </i>2020).
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