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Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.

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Title: Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.
Authors: Lin KH; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Rutter JC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Xie A; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Pardieu B; Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France., Winn ET; Division of Applied Mathematics, Brown University, Providence, RI, USA., Bello RD; Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France.; Department of Hematology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Forget A; Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France., Itzykson R; Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France.; Service Hématologie Adultes, AP-HP, Hôpital Saint-Louis, Paris, France., Ahn YR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Dai Z; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Sobhan RT; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Anderson GR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Singleton KR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Decker AE; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Winter PS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Locasale JW; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Crawford L; Department of Biostatistics, Brown University, Providence, RI, USA., Puissant A; Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France. alexandre.puissant@inserm.fr., Wood KC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA. kris.wood@duke.edu.
Source: Nature genetics [Nat Genet] 2020 Apr; Vol. 52 (4), pp. 408-417. Date of Electronic Publication: 2020 Mar 16.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.
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  Data: <searchLink fieldCode="AU" term="%22Lin+KH%22">Lin KH</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Rutter+JC%22">Rutter JC</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Xie+A%22">Xie A</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Pardieu+B%22">Pardieu B</searchLink>; Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France.<br /><searchLink fieldCode="AU" term="%22Winn+ET%22">Winn ET</searchLink>; Division of Applied Mathematics, Brown University, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Bello+RD%22">Bello RD</searchLink>; Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France.; Department of Hematology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Forget+A%22">Forget A</searchLink>; Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France.<br /><searchLink fieldCode="AU" term="%22Itzykson+R%22">Itzykson R</searchLink>; Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France.; Service Hématologie Adultes, AP-HP, Hôpital Saint-Louis, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ahn+YR%22">Ahn YR</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Dai+Z%22">Dai Z</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Sobhan+RT%22">Sobhan RT</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+GR%22">Anderson GR</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Singleton+KR%22">Singleton KR</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Decker+AE%22">Decker AE</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Winter+PS%22">Winter PS</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Locasale+JW%22">Locasale JW</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Crawford+L%22">Crawford L</searchLink>; Department of Biostatistics, Brown University, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Puissant+A%22">Puissant A</searchLink>; Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France. alexandre.puissant@inserm.fr.<br /><searchLink fieldCode="AU" term="%22Wood+KC%22">Wood KC</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA. kris.wood@duke.edu.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2020 Apr; Vol. 52 (4), pp. 408-417. <i>Date of Electronic Publication: </i>2020 Mar 16.
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