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A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma.

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Title: A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma.
Authors: Kong LR; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csiklr@nus.edu.sg.; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK. csiklr@nus.edu.sg., Mohamed Salleh NAB; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Ong RW; Laboratory of Molecular Endocrinology, National Cancer Centre Singapore, Singapore, 169610, Singapore., Tan TZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Syn NL; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore., Goh RM; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore., Fhu CW; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Tan DSW; Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore, Singapore, 169610, Singapore.; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore.; Genome Institute of Singapore, Agency for Science, Technology & Research (A*STAR), Singapore, 138672, Singapore., Iyer NG; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Office of Clinical Sciences, Duke-NUS Medical School, Singapore, 169857, Singapore.; Division of Surgical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore., Kannan S; Bioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), Singapore, 138671, Singapore., Verma CS; Bioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), Singapore, 138671, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, 119228, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, 639798, Singapore., Lim YC; Department of Pathology, National University Health System, Singapore, 119074, Singapore., Soo R; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore., Ho J; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore., Huang Y; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore., Lim JSJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore., Yan BJ; Department of Pathology, National University Health System, Singapore, 119074, Singapore., Nga ME; Department of Pathology, National University Health System, Singapore, 119074, Singapore., Lim SG; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Division of Gastroenterology and Hepatology, National University Health System, Singapore, 119074, Singapore., Koeffler HP; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Department of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Lee SC; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore., Kappei D; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Hung HT; Laboratory of Molecular Endocrinology, National Cancer Centre Singapore, Singapore, 169610, Singapore., Goh BC; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. phcgbc@nus.edu.sg.; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore. phcgbc@nus.edu.sg.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. phcgbc@nus.edu.sg.
Source: Nature communications [Nat Commun] 2020 Mar 25; Vol. 11 (1), pp. 1556. Date of Electronic Publication: 2020 Mar 25.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Kong+LR%22">Kong LR</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csiklr@nus.edu.sg.; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK. csiklr@nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Mohamed+Salleh+NAB%22">Mohamed Salleh NAB</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+RW%22">Ong RW</searchLink>; Laboratory of Molecular Endocrinology, National Cancer Centre Singapore, Singapore, 169610, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+TZ%22">Tan TZ</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.<br /><searchLink fieldCode="AU" term="%22Syn+NL%22">Syn NL</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+RM%22">Goh RM</searchLink>; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Fhu+CW%22">Fhu CW</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+DSW%22">Tan DSW</searchLink>; Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore, Singapore, 169610, Singapore.; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore.; Genome Institute of Singapore, Agency for Science, Technology & Research (A*STAR), Singapore, 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Iyer+NG%22">Iyer NG</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Office of Clinical Sciences, Duke-NUS Medical School, Singapore, 169857, Singapore.; Division of Surgical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore.<br /><searchLink fieldCode="AU" term="%22Kannan+S%22">Kannan S</searchLink>; Bioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), Singapore, 138671, Singapore.<br /><searchLink fieldCode="AU" term="%22Verma+CS%22">Verma CS</searchLink>; Bioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), Singapore, 138671, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, 119228, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, 639798, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+YC%22">Lim YC</searchLink>; Department of Pathology, National University Health System, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Soo+R%22">Soo R</searchLink>; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Ho+J%22">Ho J</searchLink>; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+JSJ%22">Lim JSJ</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Yan+BJ%22">Yan BJ</searchLink>; Department of Pathology, National University Health System, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Nga+ME%22">Nga ME</searchLink>; Department of Pathology, National University Health System, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+SG%22">Lim SG</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Division of Gastroenterology and Hepatology, National University Health System, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Koeffler+HP%22">Koeffler HP</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Department of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Lee+SC%22">Lee SC</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Kappei+D%22">Kappei D</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.<br /><searchLink fieldCode="AU" term="%22Hung+HT%22">Hung HT</searchLink>; Laboratory of Molecular Endocrinology, National Cancer Centre Singapore, Singapore, 169610, Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+BC%22">Goh BC</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. phcgbc@nus.edu.sg.; Department of Hematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore. phcgbc@nus.edu.sg.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. phcgbc@nus.edu.sg.
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