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Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia.

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Title: Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia.
Authors: Laurent AP; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.; Université Paris Diderot, Paris, France., Siret A; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France., Ignacimouttou C; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France., Panchal K; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia., Diop M; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France., Jenni S; Department of Pediatric Oncology, Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland., Tsai YC; Department of Pediatric Oncology, Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland., Roos-Weil D; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France., Aid Z; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France., Prade N; Centre of Research on Cancer of Toulouse (CRCT), CHU Toulouse, Université Toulouse III, Toulouse, France., Lagarde S; Centre of Research on Cancer of Toulouse (CRCT), CHU Toulouse, Université Toulouse III, Toulouse, France., Plassard D; IGBMC, Plateforme GenomEast, UMR7104 CNRS, Ilkirch, France., Pierron G; Service de Génétique, Institut Curie, Paris, France., Daudigeos E; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France., Lecluse Y; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France., Droin N; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France., Bornhauser BC; Department of Pediatric Oncology, Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland., Cheung LC; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.; School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Australia., Crispino JD; Division of Hematology/Oncology, Northwestern University, Chicago, Illinois., Gaudry M; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France., Bernard OA; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France., Macintyre E; Hematology, Université de Paris, Institut Necker-Enfants Malades and Assistance Publique-Hopitaux de Paris, Paris, France., Barin Bonnigal C; Centre Hospitalier Universitaire de Tours, Tours, France., Kotecha RS; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.; School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Australia.; Department of Clinical Haematology, Oncology and Bone Marrow Transplantation, Perth Children's Hospital, Perth, Australia., Geoerger B; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France., Ballerini P; Laboratoire d'Hématologie, Hôpital Trousseau, APHP, Paris-Sorbonne, Paris, France., Bourquin JP; Department of Pediatric Oncology, Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland., Delabesse E; Centre of Research on Cancer of Toulouse (CRCT), CHU Toulouse, Université Toulouse III, Toulouse, France., Mercher T; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.; Equipe Labellisée Ligue Nationale Contre le Cancer, Paris, France., Malinge S; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France. sebastien.malinge@telethonkids.org.au.; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Jul 01; Vol. 26 (13), pp. 3307-3318. Date of Electronic Publication: 2020 Mar 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Laurent+AP%22">Laurent AP</searchLink>; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.; Université Paris Diderot, Paris, France.<br /><searchLink fieldCode="AU" term="%22Siret+A%22">Siret A</searchLink>; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Ignacimouttou+C%22">Ignacimouttou C</searchLink>; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Panchal+K%22">Panchal K</searchLink>; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.<br /><searchLink fieldCode="AU" term="%22Diop+M%22">Diop M</searchLink>; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Jenni+S%22">Jenni S</searchLink>; Department of Pediatric Oncology, Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tsai+YC%22">Tsai YC</searchLink>; Department of Pediatric Oncology, Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Roos-Weil+D%22">Roos-Weil D</searchLink>; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Aid+Z%22">Aid Z</searchLink>; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Prade+N%22">Prade N</searchLink>; Centre of Research on Cancer of Toulouse (CRCT), CHU Toulouse, Université Toulouse III, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Lagarde+S%22">Lagarde S</searchLink>; Centre of Research on Cancer of Toulouse (CRCT), CHU Toulouse, Université Toulouse III, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Plassard+D%22">Plassard D</searchLink>; IGBMC, Plateforme GenomEast, UMR7104 CNRS, Ilkirch, France.<br /><searchLink fieldCode="AU" term="%22Pierron+G%22">Pierron G</searchLink>; Service de Génétique, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Daudigeos+E%22">Daudigeos E</searchLink>; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Lecluse+Y%22">Lecluse Y</searchLink>; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Droin+N%22">Droin N</searchLink>; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Bornhauser+BC%22">Bornhauser BC</searchLink>; Department of Pediatric Oncology, Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cheung+LC%22">Cheung LC</searchLink>; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.; School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Australia.<br /><searchLink fieldCode="AU" term="%22Crispino+JD%22">Crispino JD</searchLink>; Division of Hematology/Oncology, Northwestern University, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Gaudry+M%22">Gaudry M</searchLink>; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Bernard+OA%22">Bernard OA</searchLink>; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Macintyre+E%22">Macintyre E</searchLink>; Hematology, Université de Paris, Institut Necker-Enfants Malades and Assistance Publique-Hopitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Barin+Bonnigal+C%22">Barin Bonnigal C</searchLink>; Centre Hospitalier Universitaire de Tours, Tours, France.<br /><searchLink fieldCode="AU" term="%22Kotecha+RS%22">Kotecha RS</searchLink>; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.; School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Australia.; Department of Clinical Haematology, Oncology and Bone Marrow Transplantation, Perth Children's Hospital, Perth, Australia.<br /><searchLink fieldCode="AU" term="%22Geoerger+B%22">Geoerger B</searchLink>; Gustave Roussy Institute Cancer Campus, Department of Pediatric and Adolescent Oncology, INSERM U1015, Equipe Labellisée Ligue Nationale Contre le Cancer, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Ballerini+P%22">Ballerini P</searchLink>; Laboratoire d'Hématologie, Hôpital Trousseau, APHP, Paris-Sorbonne, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bourquin+JP%22">Bourquin JP</searchLink>; Department of Pediatric Oncology, Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Delabesse+E%22">Delabesse E</searchLink>; Centre of Research on Cancer of Toulouse (CRCT), CHU Toulouse, Université Toulouse III, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Mercher+T%22">Mercher T</searchLink>; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France.; Equipe Labellisée Ligue Nationale Contre le Cancer, Paris, France.<br /><searchLink fieldCode="AU" term="%22Malinge+S%22">Malinge S</searchLink>; INSERM U1170, Gustave Roussy Institute, Université Paris Saclay, Villejuif, France. sebastien.malinge@telethonkids.org.au.; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2020 Jul 01; Vol. 26 (13), pp. 3307-3318. <i>Date of Electronic Publication: </i>2020 Mar 27.
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