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CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.

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Title: CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.
Authors: Han K; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. kyuhohan@stanford.edu., Pierce SE; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA., Li A; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Spees K; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Anderson GR; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Seoane JA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Lo YH; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Dubreuil M; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA., Olivas M; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Kamber RA; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Wainberg M; Department of Computer Science, Stanford University, Stanford, CA, USA., Kostyrko K; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA., Kelly MR; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA., Yousefi M; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Simpkins SW; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Yao D; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Lee K; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Kuo CJ; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Jackson PK; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA.; Baxter Laboratory, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Sweet-Cordero A; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA., Kundaje A; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Gentles AJ; Departments of Medicine and Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA., Curtis C; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Winslow MM; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Bassik MC; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. bassik@stanford.edu.; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA. bassik@stanford.edu.; Program in Chemistry, Engineering and Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA. bassik@stanford.edu.
Source: Nature [Nature] 2020 Apr; Vol. 580 (7801), pp. 136-141. Date of Electronic Publication: 2020 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA.; Baxter Laboratory, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sweet-Cordero+A%22">Sweet-Cordero A</searchLink>; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kundaje+A%22">Kundaje A</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gentles+AJ%22">Gentles AJ</searchLink>; Departments of Medicine and Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Curtis+C%22">Curtis C</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA.; 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