First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.
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| Title: | First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers. |
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| Authors: | Van Eldik LJ; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky, USA., Sawaki L; Department of Physical Medicine & Rehabilitation, University of Kentucky, Lexington, Kentucky, USA., Bowen K; Bluegrass Research Consultants, Inc., Versailles, Kentucky, USA., Laskowitz DT; Department of Neurology, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA., Noveck RJ; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA., Hauser B; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA., Jordan L; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA., Spears TG; Duke Clinical Research Institute, Durham, North Carolina, USA., Wu H; Duke Clinical Research Institute, Durham, North Carolina, USA., Watt K; Duke Clinical Research Institute, Durham, North Carolina, USA., Raja S; Department of Neurology, Duke University, Durham, North Carolina, USA.; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA., Roy SM; Department of Pharmacology, Northwestern University, Chicago, Illinois, USA., Watterson DM; Department of Pharmacology, Northwestern University, Chicago, Illinois, USA., Guptill JT; Department of Neurology, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA. |
| Source: | Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Feb; Vol. 10 (2), pp. 131-143. Date of Electronic Publication: 2020 Apr 07. |
| Publication Type: | Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 101572899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2160-7648 (Electronic) Linking ISSN: 2160763X NLM ISO Abbreviation: Clin Pharmacol Drug Dev Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2160-7648 |
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| DOI: | 10.1002/cpdd.795 |
