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First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.

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Title: First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.
Authors: Van Eldik LJ; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky, USA., Sawaki L; Department of Physical Medicine & Rehabilitation, University of Kentucky, Lexington, Kentucky, USA., Bowen K; Bluegrass Research Consultants, Inc., Versailles, Kentucky, USA., Laskowitz DT; Department of Neurology, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA., Noveck RJ; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA., Hauser B; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA., Jordan L; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA., Spears TG; Duke Clinical Research Institute, Durham, North Carolina, USA., Wu H; Duke Clinical Research Institute, Durham, North Carolina, USA., Watt K; Duke Clinical Research Institute, Durham, North Carolina, USA., Raja S; Department of Neurology, Duke University, Durham, North Carolina, USA.; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA., Roy SM; Department of Pharmacology, Northwestern University, Chicago, Illinois, USA., Watterson DM; Department of Pharmacology, Northwestern University, Chicago, Illinois, USA., Guptill JT; Department of Neurology, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA.
Source: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Feb; Vol. 10 (2), pp. 131-143. Date of Electronic Publication: 2020 Apr 07.
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101572899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2160-7648 (Electronic) Linking ISSN: 2160763X NLM ISO Abbreviation: Clin Pharmacol Drug Dev Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.
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  Data: <searchLink fieldCode="AU" term="%22Van+Eldik+LJ%22">Van Eldik LJ</searchLink>; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Sawaki+L%22">Sawaki L</searchLink>; Department of Physical Medicine & Rehabilitation, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Bowen+K%22">Bowen K</searchLink>; Bluegrass Research Consultants, Inc., Versailles, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Laskowitz+DT%22">Laskowitz DT</searchLink>; Department of Neurology, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Noveck+RJ%22">Noveck RJ</searchLink>; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Hauser+B%22">Hauser B</searchLink>; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Jordan+L%22">Jordan L</searchLink>; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Spears+TG%22">Spears TG</searchLink>; Duke Clinical Research Institute, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Duke Clinical Research Institute, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Watt+K%22">Watt K</searchLink>; Duke Clinical Research Institute, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Raja+S%22">Raja S</searchLink>; Department of Neurology, Duke University, Durham, North Carolina, USA.; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Roy+SM%22">Roy SM</searchLink>; Department of Pharmacology, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Watterson+DM%22">Watterson DM</searchLink>; Department of Pharmacology, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Guptill+JT%22">Guptill JT</searchLink>; Department of Neurology, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Durham, North Carolina, USA.; Duke Early Phase Clinical Research Unit, Durham, North Carolina, USA.
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  Data: <searchLink fieldCode="JN" term="%22101572899%22">Clinical pharmacology in drug development</searchLink> [Clin Pharmacol Drug Dev] 2021 Feb; Vol. 10 (2), pp. 131-143. <i>Date of Electronic Publication: </i>2020 Apr 07.
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