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Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.

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Title: Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.
Authors: Chung KM; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA., Singh J; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Biology Institute, Yale University, West Haven, CT 06516, USA., Lawres L; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Biology Institute, Yale University, West Haven, CT 06516, USA., Dorans KJ; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA., Garcia C; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Biology Institute, Yale University, West Haven, CT 06516, USA., Burkhardt DB; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Robbins R; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA., Bhutkar A; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA., Cardone R; Departments of Internal Medicine and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA., Zhao X; Departments of Internal Medicine and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA., Babic A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02114, USA., Vayrynen SA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02114, USA., Dias Costa A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02114, USA., Nowak JA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Chang DT; Department of Radiation Oncology, Stanford Cancer Institute, Stanford, CA 94305, USA., Dunne RF; Division of Hematology and Oncology, Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14627, USA., Hezel AF; Division of Hematology and Oncology, Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14627, USA., Koong AC; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wilhelm JJ; Schulze Diabetes Institute and Department of Surgery, University of Minnesota Medical Center, Minneapolis, MN 55454, USA., Bellin MD; Schulze Diabetes Institute and Department of Surgery, University of Minnesota Medical Center, Minneapolis, MN 55454, USA; Department of Pediatrics, University of Minnesota Medical Center, Minneapolis, MN 55454, USA., Nylander V; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Gloyn AL; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK., Kibbey RG; Departments of Internal Medicine and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA., Krishnaswamy S; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02114, USA., Jacks T; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Fuchs CS; Yale Cancer Center, Smilow Cancer Hospital, New Haven, CT 06511, USA., Muzumdar MD; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Biology Institute, Yale University, West Haven, CT 06516, USA; Yale Cancer Center, Smilow Cancer Hospital, New Haven, CT 06511, USA. Electronic address: mandar.muzumdar@yale.edu.
Source: Cell [Cell] 2020 May 14; Vol. 181 (4), pp. 832-847.e18. Date of Electronic Publication: 2020 Apr 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Chung+KM%22">Chung KM</searchLink>; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Singh+J%22">Singh J</searchLink>; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Biology Institute, Yale University, West Haven, CT 06516, USA.<br /><searchLink fieldCode="AU" term="%22Lawres+L%22">Lawres L</searchLink>; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Biology Institute, Yale University, West Haven, CT 06516, USA.<br /><searchLink fieldCode="AU" term="%22Dorans+KJ%22">Dorans KJ</searchLink>; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Garcia+C%22">Garcia C</searchLink>; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Biology Institute, Yale University, West Haven, CT 06516, USA.<br /><searchLink fieldCode="AU" term="%22Burkhardt+DB%22">Burkhardt DB</searchLink>; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+R%22">Robbins R</searchLink>; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Bhutkar+A%22">Bhutkar A</searchLink>; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Cardone+R%22">Cardone R</searchLink>; Departments of Internal Medicine and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Departments of Internal Medicine and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Babic+A%22">Babic A</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Vayrynen+SA%22">Vayrynen SA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Dias+Costa+A%22">Dias Costa A</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Nowak+JA%22">Nowak JA</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Chang+DT%22">Chang DT</searchLink>; Department of Radiation Oncology, Stanford Cancer Institute, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Dunne+RF%22">Dunne RF</searchLink>; Division of Hematology and Oncology, Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14627, USA.<br /><searchLink fieldCode="AU" term="%22Hezel+AF%22">Hezel AF</searchLink>; Division of Hematology and Oncology, Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14627, USA.<br /><searchLink fieldCode="AU" term="%22Koong+AC%22">Koong AC</searchLink>; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Wilhelm+JJ%22">Wilhelm JJ</searchLink>; Schulze Diabetes Institute and Department of Surgery, University of Minnesota Medical Center, Minneapolis, MN 55454, USA.<br /><searchLink fieldCode="AU" term="%22Bellin+MD%22">Bellin MD</searchLink>; Schulze Diabetes Institute and Department of Surgery, University of Minnesota Medical Center, Minneapolis, MN 55454, USA; Department of Pediatrics, University of Minnesota Medical Center, Minneapolis, MN 55454, USA.<br /><searchLink fieldCode="AU" term="%22Nylander+V%22">Nylander V</searchLink>; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Gloyn+AL%22">Gloyn AL</searchLink>; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK.<br /><searchLink fieldCode="AU" term="%22McCarthy+MI%22">McCarthy MI</searchLink>; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK.<br /><searchLink fieldCode="AU" term="%22Kibbey+RG%22">Kibbey RG</searchLink>; Departments of Internal Medicine and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Krishnaswamy+S%22">Krishnaswamy S</searchLink>; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Wolpin+BM%22">Wolpin BM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Jacks+T%22">Jacks T</searchLink>; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Fuchs+CS%22">Fuchs CS</searchLink>; Yale Cancer Center, Smilow Cancer Hospital, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Muzumdar+MD%22">Muzumdar MD</searchLink>; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Biology Institute, Yale University, West Haven, CT 06516, USA; Yale Cancer Center, Smilow Cancer Hospital, New Haven, CT 06511, USA. Electronic address: mandar.muzumdar@yale.edu.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2020 May 14; Vol. 181 (4), pp. 832-847.e18. <i>Date of Electronic Publication: </i>2020 Apr 17.
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