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Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial.

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Title: Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial.
Authors: Folegatti PM; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Bittaye M; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Flaxman A; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lopez FR; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Bellamy D; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kupke A; Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, Thematic Translational Unit Emerging Infections, Marburg, Germany., Mair C; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Makinson R; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Sheridan J; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Rohde C; Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, Thematic Translational Unit Emerging Infections, Marburg, Germany., Halwe S; Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, Thematic Translational Unit Emerging Infections, Marburg, Germany., Jeong Y; International Vaccine Institute, Science Unit, Seoul, South Korea., Park YS; International Vaccine Institute, Science Unit, Seoul, South Korea., Kim JO; International Vaccine Institute, Science Unit, Seoul, South Korea., Song M; International Vaccine Institute, Science Unit, Seoul, South Korea., Boyd A; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Tran N; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Silman D; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Poulton I; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Datoo M; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Marshall J; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Themistocleous Y; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lawrie A; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Roberts R; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Berrie E; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Becker S; Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, Thematic Translational Unit Emerging Infections, Marburg, Germany., Lambe T; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hill A; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ewer K; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Gilbert S; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address: sarah.gilbert@ndm.ox.ac.uk.
Source: The Lancet. Infectious diseases [Lancet Infect Dis] 2020 Jul; Vol. 20 (7), pp. 816-826. Date of Electronic Publication: 2020 Apr 21.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE
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  Data: Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial.
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  Data: <searchLink fieldCode="AU" term="%22Folegatti+PM%22">Folegatti PM</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bittaye+M%22">Bittaye M</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Flaxman+A%22">Flaxman A</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lopez+FR%22">Lopez FR</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bellamy+D%22">Bellamy D</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kupke+A%22">Kupke A</searchLink>; Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, Thematic Translational Unit Emerging Infections, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mair+C%22">Mair C</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Makinson+R%22">Makinson R</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Sheridan+J%22">Sheridan J</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rohde+C%22">Rohde C</searchLink>; Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, Thematic Translational Unit Emerging Infections, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Halwe+S%22">Halwe S</searchLink>; Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, Thematic Translational Unit Emerging Infections, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jeong+Y%22">Jeong Y</searchLink>; International Vaccine Institute, Science Unit, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+YS%22">Park YS</searchLink>; International Vaccine Institute, Science Unit, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JO%22">Kim JO</searchLink>; International Vaccine Institute, Science Unit, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Song+M%22">Song M</searchLink>; International Vaccine Institute, Science Unit, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Boyd+A%22">Boyd A</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tran+N%22">Tran N</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Silman+D%22">Silman D</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Poulton+I%22">Poulton I</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Datoo+M%22">Datoo M</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Marshall+J%22">Marshall J</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Themistocleous+Y%22">Themistocleous Y</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lawrie+A%22">Lawrie A</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+R%22">Roberts R</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Berrie+E%22">Berrie E</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Becker+S%22">Becker S</searchLink>; Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, Thematic Translational Unit Emerging Infections, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lambe+T%22">Lambe T</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hill+A%22">Hill A</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ewer+K%22">Ewer K</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gilbert+S%22">Gilbert S</searchLink>; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address: sarah.gilbert@ndm.ox.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101130150%22">The Lancet. Infectious diseases</searchLink> [Lancet Infect Dis] 2020 Jul; Vol. 20 (7), pp. 816-826. <i>Date of Electronic Publication: </i>2020 Apr 21.
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