Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding.
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| Title: | Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding. |
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| Authors: | Yu J; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China., Gimenez LE; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA., Hernandez CC; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA., Wu Y; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China., Wein AH; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Han GW; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., McClary K; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Mittal SR; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Burdsall K; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Stauch B; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Wu L; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China., Stevens SN; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China., Peisley A; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA., Williams SY; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA., Chen V; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA., Millhauser GL; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA., Zhao S; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Cone RD; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. rcone@umich.edu stevens@shanghaitech.edu.cn.; Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Stevens RC; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China. rcone@umich.edu stevens@shanghaitech.edu.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA. |
| Source: | Science (New York, N.Y.) [Science] 2020 Apr 24; Vol. 368 (6489), pp. 428-433. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.aaz8995 |
