View in EDS HTML Full Text PDF Full Text

Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding.

Saved in:
Bibliographic Details
Title: Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding.
Authors: Yu J; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China., Gimenez LE; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA., Hernandez CC; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA., Wu Y; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China., Wein AH; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Han GW; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., McClary K; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Mittal SR; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Burdsall K; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Stauch B; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Wu L; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China., Stevens SN; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China., Peisley A; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA., Williams SY; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA., Chen V; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA., Millhauser GL; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA., Zhao S; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Cone RD; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. rcone@umich.edu stevens@shanghaitech.edu.cn.; Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Stevens RC; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China. rcone@umich.edu stevens@shanghaitech.edu.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
Source: Science (New York, N.Y.) [Science] 2020 Apr 24; Vol. 368 (6489), pp. 428-433.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 32327598
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Determination of the melanocortin-4 receptor structure identifies Ca<superscript>2+</superscript> as a cofactor for ligand binding.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Gimenez+LE%22">Gimenez LE</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez+CC%22">Hernandez CC</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Wein+AH%22">Wein AH</searchLink>; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22Han+GW%22">Han GW</searchLink>; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22McClary+K%22">McClary K</searchLink>; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22Mittal+SR%22">Mittal SR</searchLink>; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22Burdsall+K%22">Burdsall K</searchLink>; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22Stauch+B%22">Stauch B</searchLink>; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Stevens+SN%22">Stevens SN</searchLink>; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Peisley+A%22">Peisley A</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Williams+SY%22">Williams SY</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Chen+V%22">Chen V</searchLink>; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA.<br /><searchLink fieldCode="AU" term="%22Millhauser+GL%22">Millhauser GL</searchLink>; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+S%22">Zhao S</searchLink>; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Cone+RD%22">Cone RD</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. rcone@umich.edu stevens@shanghaitech.edu.cn.; Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Stevens+RC%22">Stevens RC</searchLink>; iHuman Institute, ShanghaiTech University, Pudong, Shanghai 201210, China. rcone@umich.edu stevens@shanghaitech.edu.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2020 Apr 24; Vol. 368 (6489), pp. 428-433.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0404511 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-9203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200368075%22">00368075 </searchLink><i>NLM ISO Abbreviation: </i>Science <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=32327598
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.aaz8995
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 428
    Titles:
      – TitleFull: Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yu J
      – PersonEntity:
          Name:
            NameFull: Gimenez LE
      – PersonEntity:
          Name:
            NameFull: Hernandez CC
      – PersonEntity:
          Name:
            NameFull: Wu Y
      – PersonEntity:
          Name:
            NameFull: Wein AH
      – PersonEntity:
          Name:
            NameFull: Han GW
      – PersonEntity:
          Name:
            NameFull: McClary K
      – PersonEntity:
          Name:
            NameFull: Mittal SR
      – PersonEntity:
          Name:
            NameFull: Burdsall K
      – PersonEntity:
          Name:
            NameFull: Stauch B
      – PersonEntity:
          Name:
            NameFull: Wu L
      – PersonEntity:
          Name:
            NameFull: Stevens SN
      – PersonEntity:
          Name:
            NameFull: Peisley A
      – PersonEntity:
          Name:
            NameFull: Williams SY
      – PersonEntity:
          Name:
            NameFull: Chen V
      – PersonEntity:
          Name:
            NameFull: Millhauser GL
      – PersonEntity:
          Name:
            NameFull: Zhao S
      – PersonEntity:
          Name:
            NameFull: Cone RD
      – PersonEntity:
          Name:
            NameFull: Stevens RC
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 24
              M: 04
              Text: 2020 Apr 24
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-electronic
              Value: 1095-9203
          Numbering:
            – Type: volume
              Value: 368
            – Type: issue
              Value: 6489
          Titles:
            – TitleFull: Science (New York, N.Y.)
              Type: main
ResultId 1