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Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.

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Title: Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.
Authors: Banks E; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Grondine M; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Bhavsar D; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Barry E; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Kettle JG; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK., Reddy VP; DMPK, Oncology R&D, AstraZeneca, Cambridge, CB10 1XL, UK., Brown C; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Wang H; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Mettetal JT; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Collins T; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK., Adeyemi O; Functional and Mechanistic Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK., Overman R; Discovery Sciences, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK., Lawson D; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Harmer AR; Functional and Mechanistic Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK., Reimer C; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Drew L; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Packer MJ; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK., Cosulich S; Projects, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK ., Jones RD; DMPK, Oncology R&D, AstraZeneca, Cambridge, CB10 1XL, UK., Shao W; Projects, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Wilson D; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK., Guichard S; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Fawell S; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA., Anjum R; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA. rana.anjum@astrazeneca.com.
Source: Science translational medicine [Sci Transl Med] 2020 Apr 29; Vol. 12 (541).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.
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  Data: <searchLink fieldCode="AU" term="%22Banks+E%22">Banks E</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Grondine+M%22">Grondine M</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Bhavsar+D%22">Bhavsar D</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Barry+E%22">Barry E</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Kettle+JG%22">Kettle JG</searchLink>; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Reddy+VP%22">Reddy VP</searchLink>; DMPK, Oncology R&D, AstraZeneca, Cambridge, CB10 1XL, UK.<br /><searchLink fieldCode="AU" term="%22Brown+C%22">Brown C</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Mettetal+JT%22">Mettetal JT</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Collins+T%22">Collins T</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Adeyemi+O%22">Adeyemi O</searchLink>; Functional and Mechanistic Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Overman+R%22">Overman R</searchLink>; Discovery Sciences, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Lawson+D%22">Lawson D</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Harmer+AR%22">Harmer AR</searchLink>; Functional and Mechanistic Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Reimer+C%22">Reimer C</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Drew+L%22">Drew L</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Packer+MJ%22">Packer MJ</searchLink>; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Cosulich+S%22">Cosulich S</searchLink>; Projects, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK .<br /><searchLink fieldCode="AU" term="%22Jones+RD%22">Jones RD</searchLink>; DMPK, Oncology R&D, AstraZeneca, Cambridge, CB10 1XL, UK.<br /><searchLink fieldCode="AU" term="%22Shao+W%22">Shao W</searchLink>; Projects, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+D%22">Wilson D</searchLink>; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Guichard+S%22">Guichard S</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Fawell+S%22">Fawell S</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Anjum+R%22">Anjum R</searchLink>; Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA. rana.anjum@astrazeneca.com.
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