Whole-slide image analysis of the tumor microenvironment identifies low B-cell content as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP.

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Title: Whole-slide image analysis of the tumor microenvironment identifies low B-cell content as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP.
Authors: Jachimowicz RD; University of Cologne,University Hospital Cologne, Cologne, Germany., Pieper L; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany., Reinke S; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany., Gontarewicz A; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany., Plütschow A; University of Cologneand University Hospital Cologne, German Hodgkin Study Group, Germany., Haverkamp H; University of Cologneand University Hospital Cologne, German Hodgkin Study Group, Germany., Frauenfeld L; Department of Pathology, University of Tübingen, Germany., Fend F; Department of Pathology, University of Tübingen, Germany., Overkamp M; Department of Pathology, University of Tübingen, Germany., Jochims F; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany., Thorns C; Department of Pathology, University Hospital Schleswig-Holstein, University of Lübeck, Germany., Leo Hansmann M; Department of Pathology, University Hospital Frankfurt, Germany., Möller P; Department of Pathology, University Hospital Ulm, Germany., Rosenwald A; Institute of Pathology, University of Würzburg, Comprehensive Cancer Center Mainfranken, Germany., Stein H; Pathodiagnostik, Berlin, Germany., Reinhardt HC; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, Germany., Borchmann P; University of Cologne, German Hodgkin Study Group, Cologne, Germany., von Tresckow B; University of Cologne, German Hodgkin Study Group, Cologne, Germany., Engert A; University of Cologne, German Hodgkin Study Group, Cologne, Germany., Klapper W; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
Source: Haematologica [Haematologica] 2021 Jun 01; Vol. 106 (6), pp. 1684-1692. Date of Electronic Publication: 2021 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
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  Data: Whole-slide image analysis of the tumor microenvironment identifies low B-cell content as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP.
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  Data: <searchLink fieldCode="AU" term="%22Jachimowicz+RD%22">Jachimowicz RD</searchLink>; University of Cologne,University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Pieper+L%22">Pieper L</searchLink>; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Reinke+S%22">Reinke S</searchLink>; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Gontarewicz+A%22">Gontarewicz A</searchLink>; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Plütschow+A%22">Plütschow A</searchLink>; University of Cologneand University Hospital Cologne, German Hodgkin Study Group, Germany.<br /><searchLink fieldCode="AU" term="%22Haverkamp+H%22">Haverkamp H</searchLink>; University of Cologneand University Hospital Cologne, German Hodgkin Study Group, Germany.<br /><searchLink fieldCode="AU" term="%22Frauenfeld+L%22">Frauenfeld L</searchLink>; Department of Pathology, University of Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Fend+F%22">Fend F</searchLink>; Department of Pathology, University of Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Overkamp+M%22">Overkamp M</searchLink>; Department of Pathology, University of Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Jochims+F%22">Jochims F</searchLink>; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Thorns+C%22">Thorns C</searchLink>; Department of Pathology, University Hospital Schleswig-Holstein, University of Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Leo+Hansmann+M%22">Leo Hansmann M</searchLink>; Department of Pathology, University Hospital Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Möller+P%22">Möller P</searchLink>; Department of Pathology, University Hospital Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Rosenwald+A%22">Rosenwald A</searchLink>; Institute of Pathology, University of Würzburg, Comprehensive Cancer Center Mainfranken, Germany.<br /><searchLink fieldCode="AU" term="%22Stein+H%22">Stein H</searchLink>; Pathodiagnostik, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Reinhardt+HC%22">Reinhardt HC</searchLink>; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, Germany.<br /><searchLink fieldCode="AU" term="%22Borchmann+P%22">Borchmann P</searchLink>; University of Cologne, German Hodgkin Study Group, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22von+Tresckow+B%22">von Tresckow B</searchLink>; University of Cologne, German Hodgkin Study Group, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Engert+A%22">Engert A</searchLink>; University of Cologne, German Hodgkin Study Group, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Klapper+W%22">Klapper W</searchLink>; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
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  Data: <searchLink fieldCode="JN" term="%220417435%22">Haematologica</searchLink> [Haematologica] 2021 Jun 01; Vol. 106 (6), pp. 1684-1692. <i>Date of Electronic Publication: </i>2021 Jun 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ferrata+Storti+Foundation%22">Ferrata Storti Foundation </searchLink><i>Country of Publication: </i>Italy <i>NLM ID: </i>0417435 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1592-8721 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203906078%22">03906078 </searchLink><i>NLM ISO Abbreviation: </i>Haematologica <i>Subsets: </i>MEDLINE
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