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T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.

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Title: T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.
Authors: Arunachalam PS; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Charles TP; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA., Joag V; Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Bollimpelli VS; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA., Scott MKD; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.; Center for Biomedical Informatics, Department of Medicine, Stanford University, Stanford, CA, USA., Wimmers F; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Burton SL; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA., Labranche CC; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Petitdemange C; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.; HIV Inflammation and Persistence Unit, Institut Pasteur, Paris, France., Gangadhara S; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA., Styles TM; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA., Quarnstrom CF; Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Walter KA; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Ketas TJ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Legere T; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA., Jagadeesh Reddy PB; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.; Pfizer, Andover, MA, USA., Kasturi SP; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA., Tsai A; BioLegend, San Diego, CA, USA., Yeung BZ; BioLegend, San Diego, CA, USA., Gupta S; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Tomai M; 3M Corporate Research and Materials Lab, Saint Paul, MN, USA., Vasilakos J; 3M Drug Delivery Systems, Saint Paul, MN, USA., Shaw GM; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kang CY; Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada., Moore JP; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Subramaniam S; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Khatri P; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.; Center for Biomedical Informatics, Department of Medicine, Stanford University, Stanford, CA, USA., Montefiori D; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Kozlowski PA; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Derdeyn CA; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA. cderdey@emory.edu., Hunter E; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA. ehunte4@emory.edu., Masopust D; Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA. masopust@umn.edu., Amara RR; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA. ramara@emory.edu., Pulendran B; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.
Source: Nature medicine [Nat Med] 2020 Jun; Vol. 26 (6), pp. 932-940. Date of Electronic Publication: 2020 May 11.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.
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Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tomai+M%22">Tomai M</searchLink>; 3M Corporate Research and Materials Lab, Saint Paul, MN, USA.<br /><searchLink fieldCode="AU" term="%22Vasilakos+J%22">Vasilakos J</searchLink>; 3M Drug Delivery Systems, Saint Paul, MN, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+GM%22">Shaw GM</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kang+CY%22">Kang CY</searchLink>; Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Moore+JP%22">Moore JP</searchLink>; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Subramaniam+S%22">Subramaniam S</searchLink>; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Khatri+P%22">Khatri P</searchLink>; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.; Center for Biomedical Informatics, Department of Medicine, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Montefiori+D%22">Montefiori D</searchLink>; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kozlowski+PA%22">Kozlowski PA</searchLink>; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Derdeyn+CA%22">Derdeyn CA</searchLink>; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA. cderdey@emory.edu.<br /><searchLink fieldCode="AU" term="%22Hunter+E%22">Hunter E</searchLink>; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA. ehunte4@emory.edu.<br /><searchLink fieldCode="AU" term="%22Masopust+D%22">Masopust D</searchLink>; Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA. masopust@umn.edu.<br /><searchLink fieldCode="AU" term="%22Amara+RR%22">Amara RR</searchLink>; Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA. ramara@emory.edu.<br /><searchLink fieldCode="AU" term="%22Pulendran+B%22">Pulendran B</searchLink>; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2020 Jun; Vol. 26 (6), pp. 932-940. <i>Date of Electronic Publication: </i>2020 May 11.
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