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γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.

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Title: γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
Authors: Lessard CB; Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA., Rodriguez E; Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, University of Florida, Gainesville, FL, 32610, USA., Ladd TB; Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA., Minter LM; Department of Veterinary and Animal Sciences, Center for Bioactive Delivery, Institute for Applied Life Sciences, and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA, 01003, USA., Osborne BA; Department of Veterinary and Animal Sciences, Center for Bioactive Delivery, Institute for Applied Life Sciences, and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA, 01003, USA., Miele L; Department of Genetics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA., Golde TE; Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA. tgolde@ufl.edu., Ran Y; Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA. yran@ufl.edu.
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2020 May 19; Vol. 12 (1), pp. 61. Date of Electronic Publication: 2020 May 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
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  Data: <searchLink fieldCode="AU" term="%22Lessard+CB%22">Lessard CB</searchLink>; Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+E%22">Rodriguez E</searchLink>; Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, University of Florida, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Ladd+TB%22">Ladd TB</searchLink>; Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Minter+LM%22">Minter LM</searchLink>; Department of Veterinary and Animal Sciences, Center for Bioactive Delivery, Institute for Applied Life Sciences, and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA, 01003, USA.<br /><searchLink fieldCode="AU" term="%22Osborne+BA%22">Osborne BA</searchLink>; Department of Veterinary and Animal Sciences, Center for Bioactive Delivery, Institute for Applied Life Sciences, and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA, 01003, USA.<br /><searchLink fieldCode="AU" term="%22Miele+L%22">Miele L</searchLink>; Department of Genetics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.<br /><searchLink fieldCode="AU" term="%22Golde+TE%22">Golde TE</searchLink>; Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA. tgolde@ufl.edu.<br /><searchLink fieldCode="AU" term="%22Ran+Y%22">Ran Y</searchLink>; Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA. yran@ufl.edu.
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  Data: <searchLink fieldCode="JN" term="%22101511643%22">Alzheimer's research & therapy</searchLink> [Alzheimers Res Ther] 2020 May 19; Vol. 12 (1), pp. 61. <i>Date of Electronic Publication: </i>2020 May 19.
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  Data: Journal Article; Research Support, N.I.H., Extramural
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101511643 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1758-9193 (Electronic) <i>NLM ISO Abbreviation: </i>Alzheimers Res Ther <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=32430033
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              Text: 2020 May 19
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