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Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity.

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Title: Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity.
Authors: Allard J; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France., Bucher S; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France., Massart J; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France., Ferron PJ; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France.; HCS Pharma, 250 rue Salvador Allende, 59120, Loos, France., Le Guillou D; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France., Loyant R; MITOLOGICS S.A.S, Faculté de Médecine, rue du Général Sarrail, 94000, Créteil, France., Daniel Y; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France., Launay Y; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France., Buron N; MITOLOGICS S.A.S, Faculté de Médecine, rue du Général Sarrail, 94000, Créteil, France., Begriche K; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France., Borgne-Sanchez A; MITOLOGICS S.A.S, Faculté de Médecine, rue du Général Sarrail, 94000, Créteil, France., Fromenty B; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France. bernard.fromenty@inserm.fr.
Source: Cell biology and toxicology [Cell Biol Toxicol] 2021 Apr; Vol. 37 (2), pp. 151-175. Date of Electronic Publication: 2020 Jun 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 8506639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6822 (Electronic) Linking ISSN: 07422091 NLM ISO Abbreviation: Cell Biol Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity.
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  Data: <searchLink fieldCode="AU" term="%22Allard+J%22">Allard J</searchLink>; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Bucher+S%22">Bucher S</searchLink>; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Massart+J%22">Massart J</searchLink>; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Ferron+PJ%22">Ferron PJ</searchLink>; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France.; HCS Pharma, 250 rue Salvador Allende, 59120, Loos, France.<br /><searchLink fieldCode="AU" term="%22Le+Guillou+D%22">Le Guillou D</searchLink>; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Loyant+R%22">Loyant R</searchLink>; MITOLOGICS S.A.S, Faculté de Médecine, rue du Général Sarrail, 94000, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Daniel+Y%22">Daniel Y</searchLink>; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Launay+Y%22">Launay Y</searchLink>; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Buron+N%22">Buron N</searchLink>; MITOLOGICS S.A.S, Faculté de Médecine, rue du Général Sarrail, 94000, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Begriche+K%22">Begriche K</searchLink>; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Borgne-Sanchez+A%22">Borgne-Sanchez A</searchLink>; MITOLOGICS S.A.S, Faculté de Médecine, rue du Général Sarrail, 94000, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Fromenty+B%22">Fromenty B</searchLink>; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1241, F-35000, Rennes, France. bernard.fromenty@inserm.fr.
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  Data: <searchLink fieldCode="JN" term="%228506639%22">Cell biology and toxicology</searchLink> [Cell Biol Toxicol] 2021 Apr; Vol. 37 (2), pp. 151-175. <i>Date of Electronic Publication: </i>2020 Jun 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>8506639 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-6822 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207422091%22">07422091 </searchLink><i>NLM ISO Abbreviation: </i>Cell Biol Toxicol <i>Subsets: </i>MEDLINE
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