Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice.

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Title: Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice.
Authors: Eguchi A; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan. akieguchi@clin.medic.mie-u.ac.jp.; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. akieguchi@clin.medic.mie-u.ac.jp.; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA. akieguchi@clin.medic.mie-u.ac.jp.; JST, PRETO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan. akieguchi@clin.medic.mie-u.ac.jp., Yan R; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA., Pan SQ; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA., Wu R; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA., Kim J; Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA., Chen Y; Bioinformatics Services, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90007, USA., Ansong C; Pacific Northwest National Laboratory, Richland, WA, USA., Smith RD; Pacific Northwest National Laboratory, Richland, WA, USA., Tempaku M; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan., Ohno-Machado L; Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA., Takei Y; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan., Feldstein AE; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA., Tsukamoto H; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA. htsukamo@med.usc.edu.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA. htsukamo@med.usc.edu.; Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA. htsukamo@med.usc.edu.
Source: Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2020 Jul; Vol. 98 (7), pp. 1021-1034. Date of Electronic Publication: 2020 Jun 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9504370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1440 (Electronic) Linking ISSN: 09462716 NLM ISO Abbreviation: J Mol Med (Berl) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice.
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  Data: <searchLink fieldCode="AU" term="%22Eguchi+A%22">Eguchi A</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan. akieguchi@clin.medic.mie-u.ac.jp.; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. akieguchi@clin.medic.mie-u.ac.jp.; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA. akieguchi@clin.medic.mie-u.ac.jp.; JST, PRETO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan. akieguchi@clin.medic.mie-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Yan+R%22">Yan R</searchLink>; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA.<br /><searchLink fieldCode="AU" term="%22Pan+SQ%22">Pan SQ</searchLink>; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA.<br /><searchLink fieldCode="AU" term="%22Wu+R%22">Wu R</searchLink>; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Bioinformatics Services, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90007, USA.<br /><searchLink fieldCode="AU" term="%22Ansong+C%22">Ansong C</searchLink>; Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+RD%22">Smith RD</searchLink>; Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Tempaku+M%22">Tempaku M</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan.<br /><searchLink fieldCode="AU" term="%22Ohno-Machado+L%22">Ohno-Machado L</searchLink>; Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Takei+Y%22">Takei Y</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan.<br /><searchLink fieldCode="AU" term="%22Feldstein+AE%22">Feldstein AE</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tsukamoto+H%22">Tsukamoto H</searchLink>; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA. htsukamo@med.usc.edu.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA. htsukamo@med.usc.edu.; Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA. htsukamo@med.usc.edu.
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  Data: <searchLink fieldCode="JN" term="%229504370%22">Journal of molecular medicine (Berlin, Germany)</searchLink> [J Mol Med (Berl)] 2020 Jul; Vol. 98 (7), pp. 1021-1034. <i>Date of Electronic Publication: </i>2020 Jun 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9504370 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1440 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209462716%22">09462716 </searchLink><i>NLM ISO Abbreviation: </i>J Mol Med (Berl) <i>Subsets: </i>MEDLINE
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