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Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics.

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Title: Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics.
Authors: Bovijn J; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK. jbovijn@well.ox.ac.uk celi@broadinstitute.org michael.holmes@ndph.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Krebs K; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia., Chen CY; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Boxall R; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Censin JC; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Ferreira T; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK., Pulit SL; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.; Department of Genetics, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands., Glastonbury CA; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK., Laber S; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Millwood IY; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Lin K; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Li L; Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing 100191, China., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Milani L; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia., Smith GD; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol BS8 2BN, UK., Walters RG; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia., Neale BM; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Lindgren CM; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK. jbovijn@well.ox.ac.uk celi@broadinstitute.org michael.holmes@ndph.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK., Holmes MV; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK. jbovijn@well.ox.ac.uk celi@broadinstitute.org michael.holmes@ndph.ox.ac.uk.; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Source: Science translational medicine [Sci Transl Med] 2020 Jun 24; Vol. 12 (549).
Publication Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics.
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  Data: <searchLink fieldCode="AU" term="%22Bovijn+J%22">Bovijn J</searchLink>; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK. jbovijn@well.ox.ac.uk celi@broadinstitute.org michael.holmes@ndph.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Krebs+K%22">Krebs K</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.<br /><searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Boxall+R%22">Boxall R</searchLink>; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; 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Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.<br /><searchLink fieldCode="AU" term="%22Laber+S%22">Laber S</searchLink>; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Millwood+IY%22">Millwood IY</searchLink>; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.<br /><searchLink fieldCode="AU" term="%22Milani+L%22">Milani L</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.<br /><searchLink fieldCode="AU" term="%22Smith+GD%22">Smith GD</searchLink>; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol BS8 2BN, UK.<br /><searchLink fieldCode="AU" term="%22Walters+RG%22">Walters RG</searchLink>; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.<br /><searchLink fieldCode="AU" term="%22Mägi+R%22">Mägi R</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.<br /><searchLink fieldCode="AU" term="%22Neale+BM%22">Neale BM</searchLink>; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Lindgren+CM%22">Lindgren CM</searchLink>; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK. jbovijn@well.ox.ac.uk celi@broadinstitute.org michael.holmes@ndph.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK.<br /><searchLink fieldCode="AU" term="%22Holmes+MV%22">Holmes MV</searchLink>; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK. jbovijn@well.ox.ac.uk celi@broadinstitute.org michael.holmes@ndph.ox.ac.uk.; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK.
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