Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics.
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| Title: | Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics. |
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| Authors: | Bovijn J; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK. jbovijn@well.ox.ac.uk celi@broadinstitute.org michael.holmes@ndph.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Krebs K; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia., Chen CY; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Boxall R; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Censin JC; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Ferreira T; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK., Pulit SL; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.; Department of Genetics, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands., Glastonbury CA; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK., Laber S; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Millwood IY; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Lin K; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Li L; Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing 100191, China., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Milani L; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia., Smith GD; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol BS8 2BN, UK., Walters RG; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia., Neale BM; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Lindgren CM; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK. jbovijn@well.ox.ac.uk celi@broadinstitute.org michael.holmes@ndph.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK., Holmes MV; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK. jbovijn@well.ox.ac.uk celi@broadinstitute.org michael.holmes@ndph.ox.ac.uk.; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK. |
| Source: | Science translational medicine [Sci Transl Med] 2020 Jun 24; Vol. 12 (549). |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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