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Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma.

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Title: Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma.
Authors: Zhang X; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Zegar T; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Weiser T; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany., Hamdan FH; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Berger BT; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany., Lucas R; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany., Balourdas DI; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany., Ladigan S; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany.; Department of Internal Medicine, Knappschaftskrankenhaus Bochum, Ruhr-University of Bochum, Bochum, Germany., Cheung PF; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Liffers ST; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Trajkovic-Arsic M; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Scheffler B; DKFZ Division of Translational Neurooncology, West German Cancer Center, DKTK partner site University Hospital Essen, Essen, Germany., Joerger AC; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany., Hahn SA; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany., Johnsen SA; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Knapp S; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany., Siveke JT; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.
Source: International journal of cancer [Int J Cancer] 2020 Nov 15; Vol. 147 (10), pp. 2847-2861. Date of Electronic Publication: 2020 Jun 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zegar+T%22">Zegar T</searchLink>; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weiser+T%22">Weiser T</searchLink>; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Hamdan+FH%22">Hamdan FH</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Berger+BT%22">Berger BT</searchLink>; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Lucas+R%22">Lucas R</searchLink>; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Balourdas+DI%22">Balourdas DI</searchLink>; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Ladigan+S%22">Ladigan S</searchLink>; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany.; Department of Internal Medicine, Knappschaftskrankenhaus Bochum, Ruhr-University of Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Cheung+PF%22">Cheung PF</searchLink>; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Liffers+ST%22">Liffers ST</searchLink>; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Trajkovic-Arsic+M%22">Trajkovic-Arsic M</searchLink>; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Scheffler+B%22">Scheffler B</searchLink>; DKFZ Division of Translational Neurooncology, West German Cancer Center, DKTK partner site University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Joerger+AC%22">Joerger AC</searchLink>; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Hahn+SA%22">Hahn SA</searchLink>; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Johnsen+SA%22">Johnsen SA</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Knapp+S%22">Knapp S</searchLink>; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Siveke+JT%22">Siveke JT</searchLink>; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.
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