Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma.
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| Title: | Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma. |
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| Authors: | Zhang X; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Zegar T; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Weiser T; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany., Hamdan FH; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Berger BT; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany., Lucas R; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany., Balourdas DI; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany., Ladigan S; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany.; Department of Internal Medicine, Knappschaftskrankenhaus Bochum, Ruhr-University of Bochum, Bochum, Germany., Cheung PF; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Liffers ST; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Trajkovic-Arsic M; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Scheffler B; DKFZ Division of Translational Neurooncology, West German Cancer Center, DKTK partner site University Hospital Essen, Essen, Germany., Joerger AC; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany., Hahn SA; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany., Johnsen SA; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Knapp S; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt, Germany.; German Cancer Network (DKTK), Frankfurt, Germany., Siveke JT; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Medicine Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site University Hospital Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany. |
| Source: | International journal of cancer [Int J Cancer] 2020 Nov 15; Vol. 147 (10), pp. 2847-2861. Date of Electronic Publication: 2020 Jun 29. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1097-0215 |
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| DOI: | 10.1002/ijc.33137 |
