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Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.

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Title: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
Authors: Gao L; Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA., Emperle M; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany., Guo Y; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Grimm SA; Division of Intramural Research, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, 27709, USA., Ren W; Department of Biochemistry, University of California, Riverside, CA, 92521, USA., Adam S; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany., Uryu H; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA., Zhang ZM; Department of Biochemistry, University of California, Riverside, CA, 92521, USA.; School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, 510632, China., Chen D; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Yin J; Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA., Dukatz M; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany., Anteneh H; Department of Biochemistry, University of California, Riverside, CA, 92521, USA., Jurkowska RZ; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.; School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK., Lu J; Department of Biochemistry, University of California, Riverside, CA, 92521, USA., Wang Y; Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA.; Department of Chemistry, University of California, Riverside, CA, 92521, USA., Bashtrykov P; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany., Wade PA; Division of Intramural Research, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, 27709, USA., Wang GG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA. greg_wang@med.unc.edu.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. greg_wang@med.unc.edu.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. greg_wang@med.unc.edu., Jeltsch A; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany. albert.jeltsch@ibtb.uni-stuttgart.de., Song J; Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA. jikui.song@ucr.edu.; Department of Biochemistry, University of California, Riverside, CA, 92521, USA. jikui.song@ucr.edu.
Source: Nature communications [Nat Commun] 2020 Jul 03; Vol. 11 (1), pp. 3355. Date of Electronic Publication: 2020 Jul 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
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  Data: <searchLink fieldCode="AU" term="%22Gao+L%22">Gao L</searchLink>; Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA.<br /><searchLink fieldCode="AU" term="%22Emperle+M%22">Emperle M</searchLink>; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.<br /><searchLink fieldCode="AU" term="%22Grimm+SA%22">Grimm SA</searchLink>; Division of Intramural Research, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, 27709, USA.<br /><searchLink fieldCode="AU" term="%22Ren+W%22">Ren W</searchLink>; Department of Biochemistry, University of California, Riverside, CA, 92521, USA.<br /><searchLink fieldCode="AU" term="%22Adam+S%22">Adam S</searchLink>; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Uryu+H%22">Uryu H</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+ZM%22">Zhang ZM</searchLink>; Department of Biochemistry, University of California, Riverside, CA, 92521, USA.; School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, 510632, China.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.<br /><searchLink fieldCode="AU" term="%22Yin+J%22">Yin J</searchLink>; Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA.<br /><searchLink fieldCode="AU" term="%22Dukatz+M%22">Dukatz M</searchLink>; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Anteneh+H%22">Anteneh H</searchLink>; Department of Biochemistry, University of California, Riverside, CA, 92521, USA.<br /><searchLink fieldCode="AU" term="%22Jurkowska+RZ%22">Jurkowska RZ</searchLink>; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.; School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Department of Biochemistry, University of California, Riverside, CA, 92521, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA.; Department of Chemistry, University of California, Riverside, CA, 92521, USA.<br /><searchLink fieldCode="AU" term="%22Bashtrykov+P%22">Bashtrykov P</searchLink>; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Wade+PA%22">Wade PA</searchLink>; Division of Intramural Research, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, 27709, USA.<br /><searchLink fieldCode="AU" term="%22Wang+GG%22">Wang GG</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA. greg_wang@med.unc.edu.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. greg_wang@med.unc.edu.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. greg_wang@med.unc.edu.<br /><searchLink fieldCode="AU" term="%22Jeltsch+A%22">Jeltsch A</searchLink>; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany. albert.jeltsch@ibtb.uni-stuttgart.de.<br /><searchLink fieldCode="AU" term="%22Song+J%22">Song J</searchLink>; Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA. jikui.song@ucr.edu.; Department of Biochemistry, University of California, Riverside, CA, 92521, USA. jikui.song@ucr.edu.
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