View in EDS

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.

Saved in:
Bibliographic Details
Title: Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
Authors: Nagle A; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Biggart A; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Be C; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland., Srinivas H; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland., Hein A; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland., Caridha D; Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Sciotti RJ; Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Pybus B; Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Kreishman-Deitrick M; Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Bursulaya B; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Lai YH; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Gao MY; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Liang F; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Mathison CJN; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Liu X; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Yeh V; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Smith J; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Lerario I; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Xie Y; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Chianelli D; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Gibney M; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Berman A; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Chen YL; Novartis Institute of Tropical Diseases, Emeryville, California 94608, United States., Jiricek J; Novartis Institute of Tropical Diseases, Emeryville, California 94608, United States., Davis LC; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Liu X; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Ballard J; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Khare S; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Eggimann FK; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland., Luneau A; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland., Groessl T; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Shapiro M; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Richmond W; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Johnson K; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Rudewicz PJ; Novartis Institute of Tropical Diseases, Emeryville, California 94608, United States., Rao SPS; Novartis Institute of Tropical Diseases, Emeryville, California 94608, United States., Thompson C; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States., Tuntland T; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Spraggon G; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Glynne RJ; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Supek F; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States., Wiesmann C; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland., Molteni V; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2020 Oct 08; Vol. 63 (19), pp. 10773-10781. Date of Electronic Publication: 2020 Jul 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 32667203
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Nagle+A%22">Nagle A</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Biggart+A%22">Biggart A</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Be+C%22">Be C</searchLink>; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Srinivas+H%22">Srinivas H</searchLink>; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hein+A%22">Hein A</searchLink>; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Caridha+D%22">Caridha D</searchLink>; Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Sciotti+RJ%22">Sciotti RJ</searchLink>; Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Pybus+B%22">Pybus B</searchLink>; Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Kreishman-Deitrick+M%22">Kreishman-Deitrick M</searchLink>; Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Bursulaya+B%22">Bursulaya B</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Lai+YH%22">Lai YH</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Gao+MY%22">Gao MY</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Liang+F%22">Liang F</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Mathison+CJN%22">Mathison CJN</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Yeh+V%22">Yeh V</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Smith+J%22">Smith J</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Lerario+I%22">Lerario I</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Xie+Y%22">Xie Y</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Chianelli+D%22">Chianelli D</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Gibney+M%22">Gibney M</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Berman+A%22">Berman A</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Chen+YL%22">Chen YL</searchLink>; Novartis Institute of Tropical Diseases, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Jiricek+J%22">Jiricek J</searchLink>; Novartis Institute of Tropical Diseases, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Davis+LC%22">Davis LC</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Ballard+J%22">Ballard J</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Khare+S%22">Khare S</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Eggimann+FK%22">Eggimann FK</searchLink>; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Luneau+A%22">Luneau A</searchLink>; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Groessl+T%22">Groessl T</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Shapiro+M%22">Shapiro M</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Richmond+W%22">Richmond W</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Johnson+K%22">Johnson K</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Rudewicz+PJ%22">Rudewicz PJ</searchLink>; Novartis Institute of Tropical Diseases, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Rao+SPS%22">Rao SPS</searchLink>; Novartis Institute of Tropical Diseases, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Thompson+C%22">Thompson C</searchLink>; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Tuntland+T%22">Tuntland T</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Spraggon+G%22">Spraggon G</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Glynne+RJ%22">Glynne RJ</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Supek+F%22">Supek F</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Wiesmann+C%22">Wiesmann C</searchLink>; Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Molteni+V%22">Molteni V</searchLink>; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California 92121, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2020 Oct 08; Vol. 63 (19), pp. 10773-10781. <i>Date of Electronic Publication: </i>2020 Jul 29.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=32667203
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.0c00499
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 10773
    Titles:
      – TitleFull: Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Nagle A
      – PersonEntity:
          Name:
            NameFull: Biggart A
      – PersonEntity:
          Name:
            NameFull: Be C
      – PersonEntity:
          Name:
            NameFull: Srinivas H
      – PersonEntity:
          Name:
            NameFull: Hein A
      – PersonEntity:
          Name:
            NameFull: Caridha D
      – PersonEntity:
          Name:
            NameFull: Sciotti RJ
      – PersonEntity:
          Name:
            NameFull: Pybus B
      – PersonEntity:
          Name:
            NameFull: Kreishman-Deitrick M
      – PersonEntity:
          Name:
            NameFull: Bursulaya B
      – PersonEntity:
          Name:
            NameFull: Lai YH
      – PersonEntity:
          Name:
            NameFull: Gao MY
      – PersonEntity:
          Name:
            NameFull: Liang F
      – PersonEntity:
          Name:
            NameFull: Mathison CJN
      – PersonEntity:
          Name:
            NameFull: Liu X
      – PersonEntity:
          Name:
            NameFull: Yeh V
      – PersonEntity:
          Name:
            NameFull: Smith J
      – PersonEntity:
          Name:
            NameFull: Lerario I
      – PersonEntity:
          Name:
            NameFull: Xie Y
      – PersonEntity:
          Name:
            NameFull: Chianelli D
      – PersonEntity:
          Name:
            NameFull: Gibney M
      – PersonEntity:
          Name:
            NameFull: Berman A
      – PersonEntity:
          Name:
            NameFull: Chen YL
      – PersonEntity:
          Name:
            NameFull: Jiricek J
      – PersonEntity:
          Name:
            NameFull: Davis LC
      – PersonEntity:
          Name:
            NameFull: Liu X
      – PersonEntity:
          Name:
            NameFull: Ballard J
      – PersonEntity:
          Name:
            NameFull: Khare S
      – PersonEntity:
          Name:
            NameFull: Eggimann FK
      – PersonEntity:
          Name:
            NameFull: Luneau A
      – PersonEntity:
          Name:
            NameFull: Groessl T
      – PersonEntity:
          Name:
            NameFull: Shapiro M
      – PersonEntity:
          Name:
            NameFull: Richmond W
      – PersonEntity:
          Name:
            NameFull: Johnson K
      – PersonEntity:
          Name:
            NameFull: Rudewicz PJ
      – PersonEntity:
          Name:
            NameFull: Rao SPS
      – PersonEntity:
          Name:
            NameFull: Thompson C
      – PersonEntity:
          Name:
            NameFull: Tuntland T
      – PersonEntity:
          Name:
            NameFull: Spraggon G
      – PersonEntity:
          Name:
            NameFull: Glynne RJ
      – PersonEntity:
          Name:
            NameFull: Supek F
      – PersonEntity:
          Name:
            NameFull: Wiesmann C
      – PersonEntity:
          Name:
            NameFull: Molteni V
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 08
              M: 10
              Text: 2020 Oct 08
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 63
            – Type: issue
              Value: 19
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1