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Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors.

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Title: Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors.
Authors: Robles O; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Jackson JJ; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Marshall L; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Talay O; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Chian D; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Cutler G; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Diokno R; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Hu DX; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Jacobson S; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Karbarz E; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Kassner PD; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Ketcham JM; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., McKinnell J; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Meleza C; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Reilly MK; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Riegler E; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Shunatona HP; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Wadsworth A; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Younai A; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Brockstedt DG; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Wustrow DJ; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States., Zibinsky M; RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2020 Aug 13; Vol. 63 (15), pp. 8584-8607. Date of Electronic Publication: 2020 Jul 28.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.0c00988