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A Buchwald-Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3-Ligase PROTACs*.

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Title: A Buchwald-Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3-Ligase PROTACs*.
Authors: Hayhow TG; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK., Borrows REA; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK., Diène CR; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK., Fairley G; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Macclesfield Campus, Etherow Building, Silk Road Industrial Estate, Macclesfield, SK10 2NA, UK., Fallan C; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK., Fillery SM; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK., Scott JS; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK., Watson DW; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK.
Source: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Dec 15; Vol. 26 (70), pp. 16818-16823. Date of Electronic Publication: 2020 Nov 03.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Buchwald-Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3-Ligase PROTACs*.
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  Data: <searchLink fieldCode="AU" term="%22Hayhow+TG%22">Hayhow TG</searchLink>; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Borrows+REA%22">Borrows REA</searchLink>; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Diène+CR%22">Diène CR</searchLink>; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Fairley+G%22">Fairley G</searchLink>; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Macclesfield Campus, Etherow Building, Silk Road Industrial Estate, Macclesfield, SK10 2NA, UK.<br /><searchLink fieldCode="AU" term="%22Fallan+C%22">Fallan C</searchLink>; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Fillery+SM%22">Fillery SM</searchLink>; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Scott+JS%22">Scott JS</searchLink>; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK.<br /><searchLink fieldCode="AU" term="%22Watson+DW%22">Watson DW</searchLink>; Medicinal Chemistry, Oncology R&D, Research and Early Development, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge, CB4 0WG, UK.
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              Text: 2020 Dec 15
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