A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131.
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| Title: | A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131. |
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| Authors: | Maes M; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK., Dyson ZA; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.; London School of Hygiene and Tropical Medicine, London, UK., Smith SE; Kymab Ltd, Babraham Research Campus, Cambridge, UK., Goulding DA; Wellcome Sanger Institute, Hinxton, UK., Ludden C; London School of Hygiene and Tropical Medicine, London, UK., Baker S; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK., Kellam P; Kymab Ltd, Babraham Research Campus, Cambridge, UK.; Department of Infectious Disease, Imperial College London, London, UK., Reece ST; Kymab Ltd, Babraham Research Campus, Cambridge, UK., Dougan G; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK., Bartholdson Scott J; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK. jb2143@cam.ac.uk. |
| Source: | Scientific reports [Sci Rep] 2020 Jul 24; Vol. 10 (1), pp. 12414. Date of Electronic Publication: 2020 Jul 24. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-020-69300-8 |
