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A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131.

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Title: A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131.
Authors: Maes M; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK., Dyson ZA; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.; London School of Hygiene and Tropical Medicine, London, UK., Smith SE; Kymab Ltd, Babraham Research Campus, Cambridge, UK., Goulding DA; Wellcome Sanger Institute, Hinxton, UK., Ludden C; London School of Hygiene and Tropical Medicine, London, UK., Baker S; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK., Kellam P; Kymab Ltd, Babraham Research Campus, Cambridge, UK.; Department of Infectious Disease, Imperial College London, London, UK., Reece ST; Kymab Ltd, Babraham Research Campus, Cambridge, UK., Dougan G; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK., Bartholdson Scott J; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK. jb2143@cam.ac.uk.
Source: Scientific reports [Sci Rep] 2020 Jul 24; Vol. 10 (1), pp. 12414. Date of Electronic Publication: 2020 Jul 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Maes+M%22">Maes M</searchLink>; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dyson+ZA%22">Dyson ZA</searchLink>; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.; London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Smith+SE%22">Smith SE</searchLink>; Kymab Ltd, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Goulding+DA%22">Goulding DA</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Ludden+C%22">Ludden C</searchLink>; London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Baker+S%22">Baker S</searchLink>; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kellam+P%22">Kellam P</searchLink>; Kymab Ltd, Babraham Research Campus, Cambridge, UK.; Department of Infectious Disease, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Reece+ST%22">Reece ST</searchLink>; Kymab Ltd, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dougan+G%22">Dougan G</searchLink>; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bartholdson+Scott+J%22">Bartholdson Scott J</searchLink>; Department of Medicine, Cambridge Institute for Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, UK. jb2143@cam.ac.uk.
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