Mechanistic cross-talk between DNA/RNA polymerase enzyme kinetics and nucleotide substrate availability in cells: Implications for polymerase inhibitor discovery.
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| Title: | Mechanistic cross-talk between DNA/RNA polymerase enzyme kinetics and nucleotide substrate availability in cells: Implications for polymerase inhibitor discovery. |
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| Authors: | Coggins SA; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA., Mahboubi B; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA., Schinazi RF; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA., Kim B; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA; Center for Drug Discovery, Children's Healthcare of Atlanta, Atlanta, Georgia, USA. Electronic address: baek.kim@emory.edu. |
| Source: | The Journal of biological chemistry [J Biol Chem] 2020 Sep 25; Vol. 295 (39), pp. 13432-13443. Date of Electronic Publication: 2020 Jul 31. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Review |
| Journal Info: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1083-351X |
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| DOI: | 10.1074/jbc.REV120.013746 |