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ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung.

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Title: ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung.
Authors: Schuijs MJ; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK., Png S; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK., Richard AC; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Tsyben A; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.; Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Hamm G; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Stockis J; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK., Garcia C; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK., Pinaud S; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK., Nicholls A; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK., Ros XR; Bioscience Asthma, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Su J; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK., Eldridge MD; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK., Riedel A; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Serrao EM; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK., Rodewald HR; Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany., Mack M; Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany., Shields JD; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Cohen ES; Bioscience Asthma, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., McKenzie ANJ; MRC Laboratory of Molecular Biology, Cambridge, UK., Goodwin RJA; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Brindle KM; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.; Department of Biochemistry, University of Cambridge, Cambridge, UK., Marioni JC; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.; EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Halim TYF; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK. Tim.Halim@cruk.cam.ac.uk.
Source: Nature immunology [Nat Immunol] 2020 Sep; Vol. 21 (9), pp. 998-1009. Date of Electronic Publication: 2020 Aug 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung.
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  Data: <searchLink fieldCode="AU" term="%22Schuijs+MJ%22">Schuijs MJ</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Png+S%22">Png S</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Richard+AC%22">Richard AC</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tsyben+A%22">Tsyben A</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.; Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hamm+G%22">Hamm G</searchLink>; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Stockis+J%22">Stockis J</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Garcia+C%22">Garcia C</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pinaud+S%22">Pinaud S</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Nicholls+A%22">Nicholls A</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ros+XR%22">Ros XR</searchLink>; Bioscience Asthma, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Su+J%22">Su J</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Eldridge+MD%22">Eldridge MD</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Riedel+A%22">Riedel A</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Serrao+EM%22">Serrao EM</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rodewald+HR%22">Rodewald HR</searchLink>; Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mack+M%22">Mack M</searchLink>; Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Shields+JD%22">Shields JD</searchLink>; MRC Cancer Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cohen+ES%22">Cohen ES</searchLink>; Bioscience Asthma, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22McKenzie+ANJ%22">McKenzie ANJ</searchLink>; MRC Laboratory of Molecular Biology, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Goodwin+RJA%22">Goodwin RJA</searchLink>; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Brindle+KM%22">Brindle KM</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.; Department of Biochemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Marioni+JC%22">Marioni JC</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.; EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Halim+TYF%22">Halim TYF</searchLink>; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK. Tim.Halim@cruk.cam.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2020 Sep; Vol. 21 (9), pp. 998-1009. <i>Date of Electronic Publication: </i>2020 Aug 03.
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