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Sleeping Beauty-engineered CAR T cells achieve antileukemic activity without severe toxicities.

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Title: Sleeping Beauty-engineered CAR T cells achieve antileukemic activity without severe toxicities.
Authors: Magnani CF; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy., Gaipa G; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy., Lussana F; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy., Belotti D; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy.; Department of Pediatrics, University of Milano-Bicocca, Milan, Italy., Gritti G; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy., Napolitano S; Clinica Pediatrica, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy., Matera G; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy., Cabiati B; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy., Buracchi C; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy., Borleri G; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy., Fazio G; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy., Zaninelli S; USS Centro di Terapia Cellulare 'G. Lanzani,' Bergamo, Italy., Tettamanti S; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy., Cesana S; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy., Colombo V; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy., Quaroni M; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy., Cazzaniga G; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy., Rovelli A; Clinica Pediatrica, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy., Biagi E; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Clinica Pediatrica, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy., Galimberti S; Bicocca Bioinformatics, Biostatistics and Bioimaging Centre, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Calabria A; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET)/IRCCS San Raffaele Scientific Institute, Milan, Italy., Benedicenti F; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET)/IRCCS San Raffaele Scientific Institute, Milan, Italy., Montini E; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET)/IRCCS San Raffaele Scientific Institute, Milan, Italy., Ferrari S; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy., Introna M; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.; USS Centro di Terapia Cellulare 'G. Lanzani,' Bergamo, Italy., Balduzzi A; Department of Pediatrics, University of Milano-Bicocca, Milan, Italy.; Clinica Pediatrica, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy., Valsecchi MG; Bicocca Bioinformatics, Biostatistics and Bioimaging Centre, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Dastoli G; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy., Rambaldi A; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.; Department of Oncology and Hematology, University of Milan, Milan, Italy., Biondi A; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy.; Clinica Pediatrica, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.
Source: The Journal of clinical investigation [J Clin Invest] 2020 Nov 02; Vol. 130 (11), pp. 6021-6033.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sleeping Beauty-engineered CAR T cells achieve antileukemic activity without severe toxicities.
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  Data: <searchLink fieldCode="AU" term="%22Magnani+CF%22">Magnani CF</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Gaipa+G%22">Gaipa G</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Lussana+F%22">Lussana F</searchLink>; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Belotti+D%22">Belotti D</searchLink>; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy.; Department of Pediatrics, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gritti+G%22">Gritti G</searchLink>; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Napolitano+S%22">Napolitano S</searchLink>; Clinica Pediatrica, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Matera+G%22">Matera G</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Cabiati+B%22">Cabiati B</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Buracchi+C%22">Buracchi C</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Borleri+G%22">Borleri G</searchLink>; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Fazio+G%22">Fazio G</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Zaninelli+S%22">Zaninelli S</searchLink>; USS Centro di Terapia Cellulare 'G. Lanzani,' Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Tettamanti+S%22">Tettamanti S</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Cesana+S%22">Cesana S</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Colombo+V%22">Colombo V</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Quaroni+M%22">Quaroni M</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Cazzaniga+G%22">Cazzaniga G</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Rovelli+A%22">Rovelli A</searchLink>; Clinica Pediatrica, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Biagi+E%22">Biagi E</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Clinica Pediatrica, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Galimberti+S%22">Galimberti S</searchLink>; Bicocca Bioinformatics, Biostatistics and Bioimaging Centre, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Calabria+A%22">Calabria A</searchLink>; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET)/IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Benedicenti+F%22">Benedicenti F</searchLink>; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET)/IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Montini+E%22">Montini E</searchLink>; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET)/IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrari+S%22">Ferrari S</searchLink>; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Introna+M%22">Introna M</searchLink>; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.; USS Centro di Terapia Cellulare 'G. Lanzani,' Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Balduzzi+A%22">Balduzzi A</searchLink>; Department of Pediatrics, University of Milano-Bicocca, Milan, Italy.; Clinica Pediatrica, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Valsecchi+MG%22">Valsecchi MG</searchLink>; Bicocca Bioinformatics, Biostatistics and Bioimaging Centre, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Dastoli+G%22">Dastoli G</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Rambaldi+A%22">Rambaldi A</searchLink>; Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.; Department of Oncology and Hematology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Biondi+A%22">Biondi A</searchLink>; Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.; Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy.; Clinica Pediatrica, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy.
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