Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza.
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| Title: | Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza. |
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| Authors: | Scott C; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom., Kankanala J; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom., Foster TL; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom., Goldhill DH; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom., Bao P; Faculty of Engineering and Physical Sciences, School of Physics and Astronomy, University of Leeds, Leeds, West Yorkshire, United Kingdom., Simmons K; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom., Pingen M; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom., Bentham M; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom., Atkins E; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom., Loundras E; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom., Elderfield R; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom., Claridge JK; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Thompson J; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom., Stilwell PR; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom., Tathineni R; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom., McKimmie CS; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom., Targett-Adams P; Pfizer UK, Sandwich, Kent, United Kingdom., Schnell JR; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Cook GP; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom., Evans S; Faculty of Engineering and Physical Sciences, School of Physics and Astronomy, University of Leeds, Leeds, West Yorkshire, United Kingdom., Barclay WS; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom., Foster R; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom., Griffin S; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom. |
| Source: | PLoS pathogens [PLoS Pathog] 2020 Aug 11; Vol. 16 (8), pp. e1008716. Date of Electronic Publication: 2020 Aug 11 (Print Publication: 2020). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 32780760 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Scott+C%22">Scott C</searchLink>; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kankanala+J%22">Kankanala J</searchLink>; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Foster+TL%22">Foster TL</searchLink>; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Goldhill+DH%22">Goldhill DH</searchLink>; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bao+P%22">Bao P</searchLink>; Faculty of Engineering and Physical Sciences, School of Physics and Astronomy, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Simmons+K%22">Simmons K</searchLink>; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pingen+M%22">Pingen M</searchLink>; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bentham+M%22">Bentham M</searchLink>; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Atkins+E%22">Atkins E</searchLink>; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Loundras+E%22">Loundras E</searchLink>; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Elderfield+R%22">Elderfield R</searchLink>; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Claridge+JK%22">Claridge JK</searchLink>; Department of Biochemistry, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Thompson+J%22">Thompson J</searchLink>; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Stilwell+PR%22">Stilwell PR</searchLink>; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tathineni+R%22">Tathineni R</searchLink>; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McKimmie+CS%22">McKimmie CS</searchLink>; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Targett-Adams+P%22">Targett-Adams P</searchLink>; Pfizer UK, Sandwich, Kent, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Schnell+JR%22">Schnell JR</searchLink>; Department of Biochemistry, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cook+GP%22">Cook GP</searchLink>; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Evans+S%22">Evans S</searchLink>; Faculty of Engineering and Physical Sciences, School of Physics and Astronomy, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Barclay+WS%22">Barclay WS</searchLink>; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Foster+R%22">Foster R</searchLink>; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Griffin+S%22">Griffin S</searchLink>; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101238921%22">PLoS pathogens</searchLink> [PLoS Pathog] 2020 Aug 11; Vol. 16 (8), pp. e1008716. <i>Date of Electronic Publication: </i>2020 Aug 11 (<i>Print Publication: </i>2020). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101238921 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1553-7374 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215537366%22">15537366 </searchLink><i>NLM ISO Abbreviation: </i>PLoS Pathog <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=32780760 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.ppat.1008716 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e1008716 Titles: – TitleFull: Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Scott C – PersonEntity: Name: NameFull: Kankanala J – PersonEntity: Name: NameFull: Foster TL – PersonEntity: Name: NameFull: Goldhill DH – PersonEntity: Name: NameFull: Bao P – PersonEntity: Name: NameFull: Simmons K – PersonEntity: Name: NameFull: Pingen M – PersonEntity: Name: NameFull: Bentham M – PersonEntity: Name: NameFull: Atkins E – PersonEntity: Name: NameFull: Loundras E – PersonEntity: Name: NameFull: Elderfield R – PersonEntity: Name: NameFull: Claridge JK – PersonEntity: Name: NameFull: Thompson J – PersonEntity: Name: NameFull: Stilwell PR – PersonEntity: Name: NameFull: Tathineni R – PersonEntity: Name: NameFull: McKimmie CS – PersonEntity: Name: NameFull: Targett-Adams P – PersonEntity: Name: NameFull: Schnell JR – PersonEntity: Name: NameFull: Cook GP – PersonEntity: Name: NameFull: Evans S – PersonEntity: Name: NameFull: Barclay WS – PersonEntity: Name: NameFull: Foster R – PersonEntity: Name: NameFull: Griffin S IsPartOfRelationships: – BibEntity: Dates: – D: 11 M: 08 Text: 2020 Aug 11 Type: published Y: 2020 Identifiers: – Type: issn-electronic Value: 1553-7374 Numbering: – Type: volume Value: 16 – Type: issue Value: 8 Titles: – TitleFull: PLoS pathogens Type: main |
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