Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza.
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| Title: | Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza. |
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| Authors: | Scott C; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom., Kankanala J; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom., Foster TL; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom., Goldhill DH; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom., Bao P; Faculty of Engineering and Physical Sciences, School of Physics and Astronomy, University of Leeds, Leeds, West Yorkshire, United Kingdom., Simmons K; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom., Pingen M; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom., Bentham M; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom., Atkins E; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom., Loundras E; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom., Elderfield R; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom., Claridge JK; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Thompson J; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom., Stilwell PR; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom., Tathineni R; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom., McKimmie CS; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom., Targett-Adams P; Pfizer UK, Sandwich, Kent, United Kingdom., Schnell JR; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Cook GP; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom., Evans S; Faculty of Engineering and Physical Sciences, School of Physics and Astronomy, University of Leeds, Leeds, West Yorkshire, United Kingdom., Barclay WS; Faculty of Medicine, Section of Virology, Imperial College, London, United Kingdom., Foster R; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom.; School of Chemistry, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom., Griffin S; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, United Kingdom.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, United Kingdom. |
| Source: | PLoS pathogens [PLoS Pathog] 2020 Aug 11; Vol. 16 (8), pp. e1008716. Date of Electronic Publication: 2020 Aug 11 (Print Publication: 2020). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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