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Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.

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Title: Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.
Authors: Hu Z; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA. Electronic address: zilun.hu@bms.com., Wang C; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Glunz PW; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Li J; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Cheadle NL; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Chen AY; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Chen XQ; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Myers JE; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Guarino VR; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Rose A; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Sack JS; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Sitkoff D; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Taylor DS; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Xu S; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Yan C; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Zhang H; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Zhang L; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Hennan J; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Adam LP; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Wexler RR; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA., Quan ML; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Nov 01; Vol. 30 (21), pp. 127495. Date of Electronic Publication: 2020 Aug 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.
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  Data: <searchLink fieldCode="AU" term="%22Hu+Z%22">Hu Z</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA. Electronic address: zilun.hu@bms.com.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Glunz+PW%22">Glunz PW</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Cheadle+NL%22">Cheadle NL</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Chen+AY%22">Chen AY</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Chen+XQ%22">Chen XQ</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Myers+JE%22">Myers JE</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Guarino+VR%22">Guarino VR</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Rose+A%22">Rose A</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Sack+JS%22">Sack JS</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Sitkoff+D%22">Sitkoff D</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+DS%22">Taylor DS</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Yan+C%22">Yan C</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Hennan+J%22">Hennan J</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Adam+LP%22">Adam LP</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Wexler+RR%22">Wexler RR</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.<br /><searchLink fieldCode="AU" term="%22Quan+ML%22">Quan ML</searchLink>; Research & Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, NJ 08543-5400, USA.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2020 Nov 01; Vol. 30 (21), pp. 127495. <i>Date of Electronic Publication: </i>2020 Aug 13.
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