Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist.
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| Title: | Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist. |
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| Authors: | Zhao J; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States. Electronic address: jzhao@crinetics.com., Chen Z; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States., Kusnetzow AK; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States., Nguyen J; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States., Rico-Bautista E; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States., Tan H; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States., Betz SF; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States., Struthers RS; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States., Zhu Y; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States. |
| Source: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Nov 01; Vol. 30 (21), pp. 127496. Date of Electronic Publication: 2020 Aug 14. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 32805408 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States. Electronic address: jzhao@crinetics.com.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Kusnetzow+AK%22">Kusnetzow AK</searchLink>; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Nguyen+J%22">Nguyen J</searchLink>; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Rico-Bautista+E%22">Rico-Bautista E</searchLink>; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Tan+H%22">Tan H</searchLink>; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Betz+SF%22">Betz SF</searchLink>; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Struthers+RS%22">Struthers RS</searchLink>; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Crinetics Pharmaceuticals, Inc., 10222 Barnes Canyon Road, San Diego, CA 92121, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2020 Nov 01; Vol. 30 (21), pp. 127496. <i>Date of Electronic Publication: </i>2020 Aug 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=32805408 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.bmcl.2020.127496 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 127496 Titles: – TitleFull: Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Zhao J – PersonEntity: Name: NameFull: Chen Z – PersonEntity: Name: NameFull: Kusnetzow AK – PersonEntity: Name: NameFull: Nguyen J – PersonEntity: Name: NameFull: Rico-Bautista E – PersonEntity: Name: NameFull: Tan H – PersonEntity: Name: NameFull: Betz SF – PersonEntity: Name: NameFull: Struthers RS – PersonEntity: Name: NameFull: Zhu Y IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: 2020 Nov 01 Type: published Y: 2020 Identifiers: – Type: issn-electronic Value: 1464-3405 Numbering: – Type: volume Value: 30 – Type: issue Value: 21 Titles: – TitleFull: Bioorganic & medicinal chemistry letters Type: main |
| ResultId | 1 |
